Results 151 to 160 of about 24,285 (335)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

open access: yesIbrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

open access: yesiMetaOmics, EarlyView.
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen   +7 more
wiley   +1 more source

Saccharomyces cerevisiae Atf1p is an alcohol acetyltransferase and a thioesterase in vitro [PDF]

open access: yes, 2017
Bull, Ian   +4 more
core   +1 more source

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger   +6 more
wiley   +1 more source

Lipid droplets in plants: turnover and stress responses

open access: yesFrontiers in Plant Science
Lipid droplets (LDs) have emerged as dynamic organelles central to plant lipid metabolism, stress adaptation, and energy homeostasis. This review synthesizes recent advances in understanding LD biogenesis and degradation in plants, highlighting conserved
Yujie Zhao   +5 more
doaj   +1 more source

GNPAT/USP30 Stabilizes DRP1 Protein to Promote Mitochondrial Fission and Functional Damage in COPD Progression

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Our previous study revealed the role of glycerol phosphate O‐acyltransferase (GNPAT) in regulating chronic obstructive pulmonary disease (COPD). However, its further mechanisms remained unclear. In this study, COPD models were established by exposing mice to cigarette smoke particulates.
Xin‐Gui Cheng   +5 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

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