Results 221 to 230 of about 6,072,971 (285)

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction. [PDF]

Cell Mol Neurobiol
Angelovski A, Hribkova H, Sedmik J, Liscakova B, Svecova O, Cesnarikova S, Amruz Cerna K, Pospisilova V, Kral M, Kolajova M, Klimes P, Bohaciakova D, Bebarova M.   +12 more
europepmc   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Safranal, a Natural Neuroprotective Compound, Modulates Plasma Iron Levels, Improves Behavioral Performance, and Demonstrates Dose-Specific Cytoprotection in Alzheimer's Disease Models. [PDF]

Int J Mol Sci
Tekin E, Koldemir Gündüz M, Yığman Z, Aydoğan Kara B, Küçük A, Arslan M.   +5 more
europepmc   +1 more source

Sotagliflozin improves cognitive deficits and attenuates neuroinflammation of Alzheimer's disease. [PDF]

Neurotherapeutics
Ning Y, Chen M, Yang H, Jia J.
europepmc   +1 more source

Optimized routing with Ant Colony Algorithms to extend network lifetime in Wireless Sensor Networks. [PDF]

Sci Rep
Kandasamy R, Karuppusamy SA.
europepmc   +1 more source

Disease-specific tau polymorphs are associated with unique protein networks across proteinopathies. [PDF]

EMBO J
Puangmalai N, Bhatt N, Suthprasertporn N, Miranda-Morales EG, Shchankin N, Samples M, Balci AE, Liew JY, Montalbano M, Zhao Y, Kayed R.   +10 more
europepmc   +1 more source

Age-related changes of FCGR3A⁺ natural killer cells and their association with elderly atopic dermatitis. [PDF]

EBioMedicine
Fang X, Li F, Gao Y, Zhang Y, Chen X, Zhang S, Luo Y, Zhou Y, Wang S, Tian J, Liu X, Li W, Yao X.   +12 more
europepmc   +1 more source

Blockchain and federated Q-learning-based secure, fault tolerant, and energy efficient framework for ad hoc networks. [PDF]

PLoS One
Tandon R, Gupta PK, Cheng X.
europepmc   +1 more source

Interpreter Use and Challenges in Primary Care.

JAMA Netw Open
Chen DW, Watanabe M, Fan A, Wu TY, Haymart MR, Hawley ST, Wallner LP.   +6 more
europepmc   +1 more source