Results 241 to 250 of about 114,385 (305)

Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease. [PDF]

Alzheimers Dement
Constantino NJ, Irmen RE, Lanning MJ, Turner SM, Ashley CC, Carroll CM, Neary EM, Rubinow D, Snipes JA, Macauley SL.   +9 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Functional connectivity patterns of the cerebellar components of intrinsic connectivity networks in clinically diagnosed probable Alzheimer's disease. [PDF]

BMC Med Imaging
Hari E, Ulasoglu-Yildiz C, Kurt E, Kahveci O, Gurvit H, Demiralp T.   +5 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

mTORC2-Na_v1.2 signaling drives early hyperexcitability in Alzheimer's disease mouse model. [PDF]

Channels (Austin)
Dvorak NM, Noebels JL.
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Brain network analysis in Alzheimer's disease and mild cognitive impairment using high-density diffuse optical tomography. [PDF]

Imaging Neurosci (Camb)
Butters E, Collins-Jones L, Mesquita RC, Acharya D, McKiernan E, Laurell AAS, Low A, Srinivasan S, O'Brien JT, Su L, Bale G.   +10 more
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration. [PDF]

Transl Neurodegener
Han WB, Liu XD, Tang CF, Zheng J, Xu TL, Xu NJ, Sun S.   +6 more
europepmc   +1 more source

Mandarin speech-based early detection of SCD: a feature-fusion residual network method. [PDF]

Alzheimers Dement
Liu Z, Che C, He G, Wu H, Cai L, Cui L, Liang L.   +6 more
europepmc   +1 more source