Results 21 to 30 of about 48,151 (224)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
IDHOCNET: A Novel ID Centric Architecture for Ad Hoc Networks
Journal of Computer Networks and Communications, 2016 Ad hoc networks lack support of infrastructure and operate in a shared bandwidth wireless environment. Presently, such networks have been realized by various adaptations in Internet Protocol (IP) architecture which was developed for infrastructure ...
Shahrukh Khalid +3 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Mobile ad-hoc networks: MANET [PDF]
Trendovi u Poslovanju, 2018 Currently in 2018, 7.6 billion people are in the world, and 8.6 billion mobile devices. As mobile phones have completely changed the meaning of the term to be available, a similar change in the wait and laptops users is, so it is only a matter of time ...
Mikarić Bratislav +2 more
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
ASEAN Journal on Science and Technology for Development, 2017 We introduce AIR, a new ant-based routing protocol for ad hoc wireless networks. AIR incorporates recent technology advances in ad hoc routing protocols, such as ring-based searching and third-party reply, while retaining the characteristics and benefits
Chye Ong Gan +2 more
doaj +1 more source
Preventing Black Hole Attacks in AODV Using RREQ Packets
Network, 2023 Ad hoc networks, formed by multiple wireless communication devices without any connection to wired or intermediary devices such as by access points, are widely used in various situations to construct flexible networks that are not restricted by ...
Yujin Nakano, Tomofumi Matsuzawa
doaj +1 more source
, 2013 {"references": ["Saleh Yousefi, Saeed Bastani, Mahmood Fathy, \"On the Performance of Safety Message Dissemination in Vehicular Ad Hoc Networks\", IEEE Fourth European Conference on Universal Multiservice Networks, European, 2007.", "Corson, Macker, \"Informational RFC 2501 MANET Performance Issues\", January 1999.", "C2C-CC: CAR 2 CAR Communication ...
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source