Results 41 to 50 of about 30,326 (264)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Autolimbal grafting in penetrating ocular injuries with limbal involvement

Journal of Ophthalmology, 2017
Background: A penetrating ocular injury with limbal involvement leads to limbal stem cell deficiency and poor corneal regeneration. Purpose: To assess treatment outcomes of primary surgical repair (PSR) involving autolimbal grafting versus ...
N.I. Bondar
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multidisciplinary rehabilitation and eye tracker-assisted communication in locked-in syndrome: a case report and literature review

Frontiers in Human Neuroscience
BackgroundLocked-in syndrome (LIS) is a rare and severe neurological condition characterized by quadriplegia and anarthria with preserved consciousness.
Qi Zhang, Weibo Tian, Xinyu Miao, Kaidan Chi, Zhe Chen, Xinyi Li, Wei Liu, Zhongliang Liu, Xiaoqin Duan   +8 more
doaj   +1 more source

New advances regarding adaptation of the vestibulo-ocular reflex [PDF]

Journal of Neurophysiology, 2019
This is a review summarizing the development of vestibulo-ocular reflex (VOR) adaptation behavior with relevance to rehabilitation over the last 10 years and examines VOR adaptation using head-on-body rotations, specifically the influence of training target contrast, position and velocity error signal, active vs.
Michael C. Schubert, Americo A. Migliaccio   +1 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections

Clinical Ophthalmology, 2008
Darlene MillerAbrams Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, Anne Bates Leach Eye Hospital, Miller School of Medicine-University of Miami, FL, USAAbstract: Moxifloxacin hydrochloride ophthalmic solution 0.5% (Vigamox®) is the
Darlene Miller
doaj  

Regional and central hemodynamics in ischemic optic neuropathy

Journal of Ophthalmology, 2018
Background: As ocular vascular disorders are a major cause of visual loss and affect working-age individuals, they are of particular social importance. Purpose: To investigate visual functions and ocular hemodynamics in ischemic optic neuropathy (ION)
N.I. Khramenko, N.V. Konovalova, O.V. Guzun   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source