Results 141 to 150 of about 5,193,405 (369)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The functional morphology of the egg-eating adaptations in the snake genus Dasypeltis
, 1952 Carl Gans
openalex +1 more source
Biochemical adaptation as a response to exercise. 1. Effect of swimming on the levels of lactic dehydrogenase, malic dehydrogenase and phosphorylase in muscles of 8-, 11- and 15-week-old rats [PDF]
, 1959 Michael Gould, W. A. Rawlinson
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Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
How Harmful are Adaptation Restrictions [PDF]
The dominant assumption in economic models of climate policy remains that adaptation will be implemented in an optimal manner. There are, however, several reasons why optimal levels of adaptation may not be attainable. This paper investigates the effects
Kelly C. de Bruin, Rob B. Dellink
core
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
The expression of integron arrays is shaped by the translation rate of cassettes
Nature CommunicationsIntegrons are key elements in the rise and spread of multidrug resistance in Gram-negative bacteria. These genetic platforms capture cassettes containing promoterless genes and stockpile them in arrays of variable length.
André Carvalho +7 more
doaj +1 more source
ADAPTATIONS IN GROWTH FACTOR REQUIREMENTS FOR LACTIC ACID BACTERIA [PDF]
, 1951 Vernon H. Cheldelin, Agnar P. Nygaard
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Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
ADAPTATION OF THE MIKULICZ OPERATION FOR THE RIGHT COLON AND RECTOSIGMOID
, 1940 R. Franklin Carter +2 more
openalex +2 more sources