Results 121 to 130 of about 2,231,009 (312)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The safety of childhood as a fundamental issue of developing preschool education

Культурно-историческая психология
Context and relevance. At the beginning of the 21st century, preschool childhood is increasingly exposed to global civilizational influences, threatening its transformation into the initial stage of organized education and upbringing of a ...
Yu.I. Rodin, O.G. Ghugainova
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Agriculture adaptation in climate change : adaptation report

, 2010
There is the need for a legal instrument that would first and foremost establish the executive powers of a new entity with overarching responsibilities and powers over all the authorities that have sectoral responsibilities for climate change.
Seychell, Martin, Muscat, Mark, Debono, Robert, Spiteri Gingell, David, Camilleri, George, Attard, George, The Climate Change Committee for Adaptation (CCCA), Sammut, Charles V., Borg, Simone, Cremona, Marco   +9 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Reconstruction of long-term hourly sea level data for Prince Edward Island, Canada

Scientific Data
Regional sea level rise has been regarded a key factor in understanding of climate change impact to coastal communities. As a vulnerable island to sea level rise and storm surges, the province of Prince Edward Island (PEI) in Canada lacks sufficient long-
Tianze Pang, Xiuquan Wang, Muhammad Qasim Mahmood, Sana Basheer   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Planning, Building and Insuring: adaptation of built environment to climate change induced increased intensity of natural hazards

, 2013
This project examines the likely impacts on the built environment of increased intensities in weather-related natural hazard events, in order to identify the possibilities of using the regulatory mechanisms of building construction, housing insurance and
Ginger, John, Leitch, Cam, Jago-Bassingthwaighte, Marianne, Henderson, David, Jacobs, Keith, Williams, Stewart, Cottrell, Alison, Gurtner, Yetta, King, David, Kim, Peter, Jayasinghe, Nandana, Booth, Kate, Jackson, Luke, Innes, Kenneth, Ewin, Carl   +14 more
core   +1 more source