Results 101 to 110 of about 2,231,009 (312)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Adaptation and Development: Whose Goals and Priorities Count?

open access: yes, 2010
It has been argued that adaptation to climate change should be integrated with development activities, and that it is time to pursue its 'mainstreaming' within such programmes (Burton 2009).
Nalau, Johanna, Heyd, T.
core  

Network governance and climate change adaptation: collaborative responses to the Queensland floods [PDF]

open access: yes, 2013
 This research examines ways to build adaptive capacity to climate change, through a case study of organisations that participated in the response to Queensland’s major flood disaster in Queensland in 2010/11.
Kym Patison, Julie Mann, Susan Kinnear
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Is adaptation. Truly an adaptation? Is adaptation. Truly an adaptation?

open access: yesIlha do Desterro, 2008
The article begins by historicizing film adaptation from the arrival of cinema, pointing out the many theoretical approaches under which the process has been seen: from the concept of “the same story told in a different medium” to a comprehensible definition such as “the process through which works can be transformed, forming an intersection of textual
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Characteristics of communication between modern preschoolers and their peers as a risk factor for the psychological safety of the kindergarten educational environment

open access: yesПсихологическая наука и образование
Context and relevance. The problem of psychological safety has not lost its relevance and acuteness in recent years. One of the important components of a safe educational environment is to ensure the conditions for the realization of the need ...
I.A. Burlakova   +3 more
doaj   +1 more source

Agenda, Hampton Roads Sea Level Rise/Flooding Adaptation Forum [PDF]

open access: yes, 2016
Agenda for the Hampton Roads Sea Level Rise/Flooding Adaptation Forum on September 29, 2016 at the Hampton University Conference Room 204, the Bemis Laboratories, 713 Orchard Road, Hampton ...
HR Adaptation Forum,   +2 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Climate change adaptation: tips for effective information sharing and networking [PDF]

open access: yes, 2015
Climate change adaptation is a multidisciplinary undertaking, requiring collaboration from diverse actors who operate in different sectors. This makes it critical to share information and share it well.
Global Adaptation Network
core   +1 more source

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