Results 101 to 110 of about 4,109,495 (307)
Психологическая наука и образованиеContext and relevance. The problem of psychological safety has not lost its relevance and acuteness in recent years. One of the important components of a safe educational environment is to ensure the conditions for the realization of the need ...
I.A. Burlakova +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Two-pass decision tree construction for unsupervised adaptation of HMM-based synthesis models [PDF]
, 2009 Hidden Markov model (HMM) -based speech synthesis systems possess several advantages over concatenative synthesis systems. One such advantage is the relative ease with which HMM-based systems are adapted to speakers not present in the training dataset ...
Gibson, Matthew
core +1 more source
Domain Adaptation for Statistical Classifiers
, 2011 The most basic assumption used in statistical learning theory is that training data and test data are drawn from the same underlying distribution. Unfortunately, in many applications, the "in-domain" test data is drawn from a distribution that is related,
Daume III, H., Marcu, D.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Locating QTL Controlling the Yield-Related Traits in Perennial Chinese Rice “Shendao3#”
AgricultureShendao3# (SD3#) exhibits perennial characteristics. Identifying the QTLs underlying the yield-related traits in SD3# provides a theoretical basis for future perennial rice breeding.
Yuxin Yan +9 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Nature CommunicationsStudying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies.
Antonia Wiegering +12 more
doaj +1 more source
Unsupervised intralingual and cross-lingual speaker adaptation for HMM-based speech synthesis using two-pass decision tree construction [PDF]
, 2010 Hidden Markov model (HMM)-based speech synthesis systems possess several advantages over concatenative synthesis systems. One such advantage is the relative ease with which HMM-based systems are adapted to speakers not present in the training dataset ...
Byrne, William, Gibson, Matthew
core