Results 81 to 90 of about 4,109,495 (307)

Institutional governance barriers for the development and implementation of climate adaptation strategies [PDF]

, 2009
In this paper we summarise the main social barriers to adaptation presented in climate literature – the inherent uncertainty of climate change, fragmentation, institutional voids, short term horizon of politicians and policies, and the motives and ...
Biesbroek, G.R., Kabat, P., Klostermann, J.E.M., Termeer, C.J.A.M.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Sexual behavior in male mice is impaired by an obesogenic-diabetogenic diet and worsened by exposure to a relevant environmental mixture of phthalates

Environment International
The decrease in male fertility observed since the beginning of the 20th century in Western countries could be linked to changes in diets and exposure to molecules from industry, such as endocrine disruptors and, among them, phthalates.
Mahiddine Lina, Parmentier Caroline, Touarssi Kaoutar, Grange-Messent Valérie, Mhaouty-Kodja Sakina, Hardin-Pouzet Hélène   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Existing evidence on the effects of climate variability and climate change on ungulates in North America: a systematic map

Environmental Evidence
Background Climate is an important driver of ungulate life-histories, population dynamics, and migratory behaviors. Climate conditions can directly impact ungulates via changes in the costs of thermoregulation and locomotion, or indirectly, via changes ...
Katherine C. Malpeli, Sarah C. Endyke, Sarah R. Weiskopf, Laura M. Thompson, Ciara G. Johnson, Katherine A. Kurth, Maxfield A. Carlin   +6 more
doaj   +1 more source

On the issue of the safety of the developing subject-spatial environment of a preschool educational organization

Психологическая наука и образование
Context and relevance. Developing the subject-spatial environment (RPPS) as one of the components of the educational environment should be safe for students. However, the safety requirements concern only the preservation of children's life and
M.Y. Paramonova, E.I. Krichevtsova, O.V. Nikiforova, I.A. Burlakova   +3 more
doaj   +1 more source

Effect of warm environment on the skin blood flow response to food intake

International Journal of Hyperthermia, 2020
Background and objective Warm exposure places high demands on thermoregulation mechanisms, which depend on the effectiveness of the microvascular function.
K. Reminy, O. Hue, S. Antoine-Jonville
doaj   +1 more source

Adaptation of speaker-specific bases in non-negative matrix factorization for single channel speech-music separation [PDF]

, 2011
This paper introduces a speaker adaptation algorithm for nonnegative matrix factorization (NMF) models. The proposed adaptation algorithm is a combination of Bayesian and subspace model adaptation. The adapted model is used to separate speech signal from
Erdoğan, Hakan, Grais, Emad Mounir
core  

Adversarial Speaker Adaptation

, 2019
We propose a novel adversarial speaker adaptation (ASA) scheme, in which adversarial learning is applied to regularize the distribution of deep hidden features in a speaker-dependent (SD) deep neural network (DNN) acoustic model to be close to that of a ...
Gong, Yifan, Li, Jinyu, Meng, Zhong
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source