Results 71 to 80 of about 2,311,593 (264)

Unsupervised cross-lingual speaker adaptation for HMM-based speech synthesis using two-pass decision tree construction [PDF]

, 2010
This paper demonstrates how unsupervised cross-lingual adaptation of HMM-based speech synthesis models may be performed without explicit knowledge of the adaptation data language.
Teemu Hirsimaki, Mikko Kurimo, Reima Karhila, Matthew Gibson, William Byrne, Karhila, Reima   +5 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sexual behavior in male mice is impaired by an obesogenic-diabetogenic diet and worsened by exposure to a relevant environmental mixture of phthalates

Environment International
The decrease in male fertility observed since the beginning of the 20th century in Western countries could be linked to changes in diets and exposure to molecules from industry, such as endocrine disruptors and, among them, phthalates.
Mahiddine Lina, Parmentier Caroline, Touarssi Kaoutar, Grange-Messent Valérie, Mhaouty-Kodja Sakina, Hardin-Pouzet Hélène   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

On the issue of the safety of the developing subject-spatial environment of a preschool educational organization

Психологическая наука и образование
Context and relevance. Developing the subject-spatial environment (RPPS) as one of the components of the educational environment should be safe for students. However, the safety requirements concern only the preservation of children's life and
M.Y. Paramonova, E.I. Krichevtsova, O.V. Nikiforova, I.A. Burlakova   +3 more
doaj   +1 more source

Genomic preselection with genotyping-by-sequencing increases performance of commercial oil palm hybrid crosses

BMC Genomics, 2017
Background There is great potential for the genetic improvement of oil palm yield. Traditional progeny tests allow accurate selection but limit the number of individuals evaluated. Genomic selection (GS) could overcome this constraint.
David Cros, Stéphanie Bocs, Virginie Riou, Enrique Ortega-Abboud, Sébastien Tisné, Xavier Argout, Virginie Pomiès, Leifi Nodichao, Zulkifli Lubis, Benoit Cochard, Tristan Durand-Gasselin   +10 more
doaj   +1 more source

The Economics of Climate Change in Zanzibar: Vulnerability, Impacts and Adaptation

, 2012
The study has undertaken a review and initial climate change assessment of vulnerability, impacts and adaptation on Zanzibar. These findings were discussed with stakeholders at workshops on Unguja and Pemba.
Global Climate Adaptation Partnership
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

How does community energy impact life from an SDG perspective?

Energy, Sustainability and Society
Background Islands present favorable conditions for testing new energy interventions due to their small-scale energy systems and distinct socio-spatial characteristics.
Philipp Baslik, Nikolas Schöne, Tim Ronan Britton, Lukas Otte, Emma Fevret, Boris Heinz   +5 more
doaj   +1 more source