Results 91 to 100 of about 2,311,593 (264)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Network governance and climate change adaptation: collaborative responses to the Queensland floods [PDF]

, 2013
 This research examines ways to build adaptive capacity to climate change, through a case study of organisations that participated in the response to Queensland’s major flood disaster in Queensland in 2010/11.
Kym Patison, Julie Mann, Susan Kinnear
core  

The limits to adaptation

, 2014
This chapter explores six case studies of climate change impacts in Australia, the scope and opportunity for adaptation, the possibility that limits to adaptation exist and their nature and causes.
Palutikof, Jean, Jean P. Palutikof, Barnett, Jon, Jon Barnett   +3 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Adaptation to climate in widespread eucalypt species [PDF]

, 2013
The long term success of revegetation efforts will depend upon the planted species’ resilience to climate change. Many widespread species grow across a range of climatic conditions and, thus, may possess adaptations that could be utilised to improve ...
Suzanne Prober, Liz McLean, Margaret Byrne   +2 more
core  

Climate change adaptation pathways

, 2013
This chapter introduces three case studies of adaptation to climate variability and change presented at the 2010 Climate Adaptation Futures Conference held on the Gold Coast, Australia.
Wandel, Johanna, Maclellan, Nic, Crick, Florence, Florence Crick, Nic Maclellan, Johanna Wandel, Katharine Vincent, Vincent, Katherine   +7 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification

Nature Communications
Studying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies.
Antonia Wiegering, Isabelle Anselme, Ludovica Brunetti, Laura Metayer-Derout, Damelys Calderon, Sophie Thomas, Stéphane Nedelec, Alexis Eschstruth, Valentina Serpieri, Martin Catala, Christophe Antoniewski, Sylvie Schneider-Maunoury, Aline Stedman   +12 more
doaj   +1 more source

Locating QTL Controlling the Yield-Related Traits in Perennial Chinese Rice “Shendao3^#”

Agriculture
Shendao3# (SD3#) exhibits perennial characteristics. Identifying the QTLs underlying the yield-related traits in SD3# provides a theoretical basis for future perennial rice breeding.
Yuxin Yan, Jiuyan Lu, Meilin Wu, Tingshen Peng, Lin Tan, Wenbin Nan, Xiaojian Qin, Ming Li, Junyi Gong, Yongshu Liang   +9 more
doaj   +1 more source

Planning, Building and Insuring: adaptation of built environment to climate change induced increased intensity of natural hazards

, 2013
This project examines the likely impacts on the built environment of increased intensities in weather-related natural hazard events, in order to identify the possibilities of using the regulatory mechanisms of building construction, housing insurance and
Ginger, John, Leitch, Cam, Jago-Bassingthwaighte, Marianne, Henderson, David, Jacobs, Keith, Williams, Stewart, Cottrell, Alison, Gurtner, Yetta, King, David, Kim, Peter, Jayasinghe, Nandana, Booth, Kate, Jackson, Luke, Innes, Kenneth, Ewin, Carl   +14 more
core   +1 more source