Results 111 to 120 of about 2,311,593 (264)

How Harmful are Adaptation Restrictions [PDF]

The dominant assumption in economic models of climate policy remains that adaptation will be implemented in an optimal manner. There are, however, several reasons why optimal levels of adaptation may not be attainable. This paper investigates the effects
Kelly C. de Bruin, Rob B. Dellink
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Reconstruction of long-term hourly sea level data for Prince Edward Island, Canada

Scientific Data
Regional sea level rise has been regarded a key factor in understanding of climate change impact to coastal communities. As a vulnerable island to sea level rise and storm surges, the province of Prince Edward Island (PEI) in Canada lacks sufficient long-
Tianze Pang, Xiuquan Wang, Muhammad Qasim Mahmood, Sana Basheer   +3 more
doaj   +1 more source

The safety of childhood as a fundamental issue of developing preschool education

Культурно-историческая психология
Context and relevance. At the beginning of the 21st century, preschool childhood is increasingly exposed to global civilizational influences, threatening its transformation into the initial stage of organized education and upbringing of a ...
Yu.I. Rodin, O.G. Ghugainova
doaj   +1 more source

A Risk Management Approach to Climate Adaptation in China

, 2013
This discussion paper provides the analytical backdrop for a series of papers on managing climate- and weather-related risks in China. It reviews and synthesizes the growing literature on risk-based management
Sall, Chris
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Co-producing climate stories as climate services for adaptation

Climate Services
As climate change adaptation becomes an increasingly urgent policy domain, the demand for effective, engaging, and usable climate services is rising. Stories – defined as structured narratives that include elements such as setting, characters, and plot -
Eva Boon, Nellie Sofie Body, Amy M.P. Oen, Sean Salazar, James Michael Strout, Sophie van der Horst, Jan-Willem Anker, Felix van Veldhoven, Timo Kelder, Hasse Goosen   +9 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source