Results 111 to 120 of about 2,231,009 (312)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Locating QTL Controlling the Yield-Related Traits in Perennial Chinese Rice “Shendao3#”
AgricultureShendao3# (SD3#) exhibits perennial characteristics. Identifying the QTLs underlying the yield-related traits in SD3# provides a theoretical basis for future perennial rice breeding.
Yuxin Yan +9 more
doaj +1 more source
Local Institutions and Climate Change Adaptation
, 2008 This note examines the relationships between climate-related vulnerabilities, adaptation practices, institutions, and external interventions to show the role and importance of local institutions in climate
Agrawal, Arun +2 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Nature CommunicationsStudying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies.
Antonia Wiegering +12 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Opportunity windows accelerate action and expand options for climate adaptation in Europe
Communications Earth & EnvironmentClimate adaptation must be intensified globally to keep up with increasing climate change impacts. To date, adaptation is mostly driven by climate risks that need to be reduced and little by opportunities. We identify opportunity windows -i.e. favourable
Valeria Di Fant +5 more
doaj +1 more source
Cross-scale barriers to climate change adaptation in local government, Australia [PDF]
, 2013 This report documents a study aimed at identifying cross-scale barriers to planned adaptation within the context of local government in Australia, and the development of enabling actions to overcome these barriers.
Herriman, E +3 more
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