Results 141 to 150 of about 2,311,593 (264)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
An Analysis of Adaptation as a Response to Climate Change [PDF]
Climate change is likely to have relevant effects on our future socio-economic systems. It is therefore important to identify how markets and policy jointly react to expected climate change to protect our societies and well-being.
Francesco Bosello +2 more
core
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Adaptation, Mitigation and Innovation: A Comprehensive Approach to Climate Policy [PDF]
The ultimate question that most interests policy makers is how to reduce the climate change vulnerability of socio-economic systems in the most cost-effective manner. Extended literature has investigated the different dimensions of mitigation strategies,
Francesco Bosello +3 more
core
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Obzornik zdravstvene nege, 1971 Neža Jarnovič; priredba/adaptation: M.J.; Stanka Simoneti; priredba/adaptation B.M.
doaj
External validation and adaptation of the Computational Barthel Index Tool in a large nursing home cohort. [PDF]
PLOS Digit HealthNgana LP +4 more
europepmc +1 more source
, 2013 This research aimed to provide practical information about how to design communications on climate change adaptation and target these to the Australian population.
Reser, Joseph +12 more
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source