Results 91 to 100 of about 1,695,526 (286)

Expressing Adaptation Strategies Using Adaptation Patterns

, 2011
Today, there is a real challenge to enable personalized access to information. Several systems have been proposed to address this challenge including Adaptive Hypermedia Systems (AHSs).
Bourda, Yolaine, Zemirline, Nadjet
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Enhancing resilience to climate change: a comprehensive PRISMA review of agricultural and non-agricultural adaptation strategies for Ghana

Cogent Social Sciences
Farming in Ghana is highly vulnerable to climate change due to factors such as limited financial resources, inadequate land availability, lack of access to technology, and insufficient public infrastructure, including roads, weather forecasting systems ...
Silas Uwumborge Takal, Abdul-Wahab Tahiru, IM Rizwanul Fattah, Samuel Jerry Cobbina, Wilhemina Asare, Samuel Kojo Abanyie   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

National perspectives on climate change adaptation: A panel discussion of climate change adaptation efforts in diverse coastal regions of the United States [PDF]

, 2010
Climate change has rapidly emerged as a significant threat to coastal areas around the world. While uncertainty regarding distribution, intensity, and timescale inhibits our ability to accurately forecast potential impacts, it is widely accepted that ...
Bohlander, Andy, Corcoran, Patrick, Rogers, Spencer, Stancioff, Esperanza   +3 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Impact of Climate Variability on the Livelihoods of Smallholder Farmers in an Agricultural Village in the Wider Belfast Area, Mpumalanga Province, South Africa

Atmosphere
The purpose of this study was to investigate the impact of climate change on smallholder farmers in South Africa, particularly focusing on the relationship between agriculture and weather patterns.
Mashford Zenda, Michael Rudolph, Charis Harley   +2 more
doaj   +1 more source

Coordinating Local Adaptive Strategies through a Network-Based Approach [PDF]

, 2018
As the impacts of climate change become increasingly destructive and pervasive, climate adaptation has received greater political and academic attention. The traditional top-down model for mitigating climate change, however, is ill-suited to implementing
Shan, Xueqing
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source