Results 91 to 100 of about 5,788,215 (257)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Learning from cross-border mechanisms to support climate change adaptation in Australia [PDF]

, 2013
The impacts of climate change do not adhere to conventional governance boundaries. Floods for example do not stop at the state border, nor are storm surges contained within local government jurisdictions.
Wendy Steele
core  

Climate Resilience Through Adaptation Among Bangladeshi Farming Communities

Food and Energy Security
Agricultural communities around the world, including those in Bangladesh, are becoming increasingly vulnerable to climate‐induced damage that jeopardizes their livelihoods and food security. While burgeoning research on adaptation exists, there is a lack
Most Nilufa Khatun, Md Sayed Iftekhar, Athula Naranpanawa, Md Nazirul Islam Sarker   +3 more
doaj   +1 more source

The Cooperation Regulation of Antioxidative System and Hormone Contents on Physiological Responses of Wedelia trilobata and Wedelia chinensis under Simulated Drought Environment

Plants
Drought-induced metabolic dysregulation significantly enhances the production of reactive oxygen species (ROS), which, in turn, exerts a substantial influence on the oxidation–reduction regulatory status of cells.
Ping Huang, Zhiwei Xu, Weijie He, Hong Yang, Bin Li, Wendian Ding, Yuze Lei, Adeel Abbas, Rashida Hameed, Congyan Wang, Jianfan Sun, Daolin Du   +11 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Climate adaptation heuristics and the science/policy divide

, 2015
The adaptation science enterprise has expanded rapidly in recent years, presumably in response to growth in demand for knowledge that can facilitate adaptation policy and practice.
Mustelin, Johanna, Maloney, Megan C, Preston, Benjamin L., C. Maloney, Megan, Nalau, Johanna, Preston, Benjamin L   +5 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Supporting Integrated and Comprehensive Approaches to Climate Change Adaptation in Africa [PDF]

, 2010
The Africa Adaptation Programme (AAP) has been designed to support the long-term efforts of targeted countries to further develop their capability to successfully identify, design and implement holistic adaptation and disaster risk reduction programmes ...
The Africa Adaptation Programme (AAP)
core  

Evolving local climate adaptation strategies: incorporating influences of socio–economic stress

, 2011
Socio-economic and climatic stresses affect local communities’ vulnerability toflooding. Better incorporation of socio-economic stress in local vulnerability assessments isimportant when planning for climate adaptation.
Glaas, Erik,, Mattias Hjerpe, Hjerpe, Mattias, Hjerpe, Mattias,, Erik Glaas, Glaas, Erik   +5 more
core   +1 more source