Results 71 to 80 of about 318,990 (310)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Perceptual–Cognitive Abilities and Reaction Performance in Female Volleyball Players: Implications for Training and Player Development

Sports
Perceptual–cognitive abilities are essential components of performance in volleyball, where players must quickly interpret visual information and respond effectively to rapidly changing game situations.
Afroditi Lola, Eleni Bassa, Georgia Stavropoulou, George Giatsis, Konstantinos Chatzinikolaou   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Prevalence of alexithymia and depression among professional contemporary French dancers

Frontiers in Sports and Active Living
BackgroundA high incidence of mental disorders has been observed in contemporary dance, characterized by the integration of physical performances with artistic demands.
Catarina Proenca Lopes, Mathias Poussel, Mathias Poussel, Eliane Albuisson, Eliane Albuisson, Eliane Albuisson, Margaux Temperelli, Oriane Hily, Bruno Chenuel, Bruno Chenuel, Edem Allado, Edem Allado   +11 more
doaj   +1 more source

INTERnational Project for the Evaluation of “activE Rehabilitation” (inter-PEER) – a protocol for a prospective cohort study of community peer-based training programmes for people with spinal cord injury

BMC Neurology, 2020
Background Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes
Anestis Divanoglou, Tomasz Tasiemski, Sophie Jörgensen   +2 more
doaj   +1 more source

Perceived professional development needs of general and adapted physical education teachers

, 2011
Students with disabilities should receive adapted physical education (APE) services from a qualified APE and! or a general physical education (GPE) teacher.
Rosenfeld, Scott S.
core  

The 'Walking for Wellbeing in the West' randomised controlled trial of a pedometer-based walking programme in combination with physical activity consultation with 12 month follow-up: rationale and study design [PDF]

, 2008
Background: Scotland has a policy aimed at increasing physical activity levels in the population, but evidence on how to achieve this is still developing.
Ward Thompson, Catharine; id_orcid, Nimmo, Myra A., Myra A Nimmo, Fitzsimons, Claire F., , Scottish Government (Funder), Baker, Graham, Graham Baker, David Ogilvie, Fenwick, Elisabeth, Wright, A, Inchley, Jo, Fenwick, E, Annemarie Wright, Foster, Charlie, Inchley, J, Millington, C, Inchley, Joanna Catherine, Ogilvie, David, Mutrie, Nanette, Charlie E Foster, Ward Thompson, C, Lowry, R, Foster, Charles, Shaw, R, Ward, Thompson C, Foster, Charlie E, Millington, Catherine, Nimmo, Myra A, Fitzsimons, CF, Baker, G, Catharine Ward Thompson, Thompson, Catharine Ward, Wright, Annemarie, Lowry, Ruth G., Ward Thompson, Catharine, Rebecca Shaw, Claire F Fitzsimons, Foster, Charlie E., Ogilvie, D, Fitzsimons, Claire, CF, Fitzsimons, Catherine Millington, Inchley, Joanna, Fitzsimons, Claire F, Foster, CE, Fenwick, Elizabeth, Lowry, Ruth, CE, Foster, MA, Nimmo, Mutrie, N, Ruth Lowry, Shaw, Rebecca, Nimmo, MA, Elisabeth Fenwick, Joanna Inchley, Nanette Mutrie, Millington, Cath   +56 more
core   +1 more source