Results 101 to 110 of about 15,574 (255)

Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation

JCI Insight
Breastfeeding provides important immunological benefits to the neonate, but how the different immunoactive components in breastmilk contribute to immunity remains poorly understood.
Elise S. Saager, Arthur H. van Stigt, Butstabong Lerkvaleekul, Lisanne Lutter, Anneke H. Hellinga, M. Marlot van der Wal, Louis J. Bont, Jeanette H.W. Leusen, Belinda van’t Land, Femke van Wijk, the Protection against Respiratory tract infections through human Milk Analysis (PRIMA) group   +10 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Intelligent mobile user profile classification for content personalisation

, 2009
Mobile device can be used as a medium to send and receive mobile internet content. Although there are several limitations using mobile internet, content personalisation have been viewed as an important area for advancing mobile internet. In this paper we
Wong, K.W., Paireekreng, W.
core  

Temporal profile and amplitude of human masseter muscle activity is adapted to food properties during individual chewing cycles

, 2014
Jaw actions adapt to the changing properties of food that occur during a masticatory sequence. In the present study, we investigated how the time-varying activation profile of the masseter muscle changes during natural chewing in humans and how food ...
Grigoriadis, A, Johansson, Roland S,, Trulsson, M   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

PERMA Profiler: Adaptation to Sinhala

KDU Journal of Multidisciplinary Studies
Recent history has seen an increased interest in wellbeing. This interest has been observed in clinical settings as well as at the level of state policies and at corporate levels. Following this interest, many models of wellbeing have been developed. The PERMA model of wellbeing was a more recent development forwarded by Martin Seligman, which measures
T. H. Solomons, S. Katriarachchi, J. Galante, D. Waas   +3 more
openaire   +1 more source

Simulation of velocity profile inside turbulent boundary layer

, 2020
The second-order differential equation with a general polynomial solution [1], is adapted for simulation of complex velocity profile inside the turbulent boundary layer.
Raić, Karlo
core   +1 more source

A Study to Investigate the Safety and Immunogenicity of Monovalent Omicron LP.8.1-Adapted BNT162b2 COVID-19 Vaccine in Adults ≥ 65 Years of Age and High-Risk Adults 18–64 Years of Age (Preliminary Results)

Vaccines
Background/Objectives: This study evaluated the Omicron LP.8.1 variant-adapted BNT162b2 mRNA vaccine (LP.8.1-adapted BNT162b2). Methods: This analysis is part of an ongoing phase 3 open-label study evaluating the immunogenicity, safety, and tolerability ...
Rucha Dadhe, Juleen Gayed, Muneeb Iqbal, Rohit Solan, Han Wu, Hua Ma, Xia Xu, Federico J. Mensa, Todd Belanger, David Cooper, Robin Mogg, Annaliesa S. Anderson, Özlem Türeci, Uǧur Şahin, Pirada Suphaphiphat Allen, Kayvon Modjarrad, Alejandra Gurtman, Kelly Lindert   +17 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

STRATIFICATED FLOW OF TWO-LAYER LUBRICATION IN THE CLEARANCE OF THRUST BEARING WITH THE INCREASED BEARING CAPACITY

Advanced Engineering Research, 2010
A method of calculation of the thrust plain bearing with adapted profile of the bearing capacity, providing the increased bearing capacity of the bearing, working on the stratified two-layer lubrication in the presence of the porous layer on the surface ...
K.S. AKHVERDIEV, E.E. ALEKSANDROVA, E.V. KRUCHININA, M.A. MUKUTADZE   +3 more
doaj