Results 111 to 120 of about 2,863,408 (296)

Identifying Ocean Submesoscale Activity From Vertical Density Profiles Using Machine Learning

Earth and Space Science
Submesoscale eddies are important features in the upper ocean where they mediate air‐sea exchanges, convey heat and tracer fluxes into ocean interior, and enhance biological production.
Leyu Yao, John R. Taylor, Dani C. Jones, Scott D. Bachman   +3 more
doaj   +1 more source

Severity-adapted graded exercise rehabilitation reduces systemic inflammation and improves functional capacity in hospitalized AECOPD: an assessor-blinded randomized controlled trial

Frontiers in Physiology
BackgroundHospitalized acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is characterized by heightened systemic inflammation and rapid decline in functional capacity.
Hui Zeng, Yue Chen, Yue Chen, Hongmin Ran, Dehua Zhao, Yan Wang, Dandan Fu, Nana Yang, Jimei Luo, Jimei Luo, Lina Ma, Qiuhang Hu, Qiuhang Hu, Lulu Huang, Lulu Huang, Changxiu Li, Luwen Luo, Rong Liu   +17 more
doaj   +1 more source

PERMA Profiler: Adaptation to Sinhala

KDU Journal of Multidisciplinary Studies
Recent history has seen an increased interest in wellbeing. This interest has been observed in clinical settings as well as at the level of state policies and at corporate levels. Following this interest, many models of wellbeing have been developed. The PERMA model of wellbeing was a more recent development forwarded by Martin Seligman, which measures
T. H. Solomons, S. Katriarachchi, J. Galante, D. Waas   +3 more
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

To Adapt or Not to Adapt? Evidence on the Latent Adaptability Profiles of Young Adults

, 2022
The world is changing, and successful adaptation to novelty lies through openness, curiosity, confidence, and a growth mindset – in other words, adaptability. Nevertheless, how can we say if one is adaptable or not? Can it be explained by one’s age, gender, or previous experience of adapting to change? Does the high level of adaptability associate with
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

General Physical Education Teachers' Perceptions of Adapted Physical Education Consultation

, 2009
\ud GENERAL PHYSICAL EDUCATION TEACHERS' PERCEPTIONS OF\ud ADAPTED PHYSICAL EDUCATION CONSULTATION\ud by\ud ?? Marcia J. Pope 2009\ud Master of Arts in Kinesiology\ud California State University, Chico\ud Summer 2009\ud This phenomenological study ...
Pope, Marcia
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source