Results 111 to 120 of about 7,062,162 (309)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
To Adapt or Not to Adapt? Evidence on the Latent Adaptability Profiles of Young Adults
, 2022 The world is changing, and successful adaptation to novelty lies through openness, curiosity, confidence, and a growth mindset – in other words, adaptability. Nevertheless, how can we say if one is adaptable or not? Can it be explained by one’s age, gender, or previous experience of adapting to change? Does the high level of adaptability associate with
openaire +1 more source
PERMA Profiler: Adaptation to Sinhala
KDU Journal of Multidisciplinary StudiesRecent history has seen an increased interest in wellbeing. This interest has been observed in clinical settings as well as at the level of state policies and at corporate levels. Following this interest, many models of wellbeing have been developed. The PERMA model of wellbeing was a more recent development forwarded by Martin Seligman, which measures
T. H. Solomons +3 more
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
VaccinesVaccination remains an important mitigation tool against COVID-19. We report 1-month safety and preliminary immunogenicity data from a substudy of an ongoing, open-label, phase 2/3 study of monovalent Omicron XBB.1.5-adapted BNT162b2 (single 30-μg dose).
Juleen Gayed +20 more
doaj +1 more source
Analysis of activity of health workers in educational organizations and needs for medical care of children with disabilities [PDF]
Саратовский научно-медицинский журнал, 2017 Objective: study of the current state of medical support for children in educational organizations and an assessment of the needs of children with disabilities in medical care. Material and Methods.
Fomina A.V. +2 more
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