Results 221 to 230 of about 7,757,834 (351)

A Case of IDH-Mutant Astrocytoma Harboring an IDH2 R172_H173delinsSN Variant. [PDF]

Neuropathology
Auen T, Chen J, Shonka N, Cathcart S.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The relationship between mobile phone dependence, self-control, and Tai Chi exercise among sub-health older adults in urban areas: a latent profile analysis. [PDF]

Front Public Health
Hao T, Wu D.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Using atomic force microscopy for physical virology: touching and manipulating single virus particles. [PDF]

Biophys Rev
Díez-Martínez A, Strobl K, Cámara-Ballesteros A, Delgado-Buscalioni R, de Pablo PJ.   +4 more
europepmc   +1 more source

Estimation of the dietary nutrient profile of free-roaming feral cats: possible implications for nutrition of domestic cats.

British Journal of Nutrition, 2011
E. Plantinga, G. Bosch, W. Hendriks
semanticscholar   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Benefit-risk profile of upadacitinib: exploratory post hoc analysis of phase 2b/3 studies in patients with moderately to severely active ulcerative colitis or Crohn's disease. [PDF]

J Crohns Colitis
Vermeire S, Colombel JF, Danese S, Panaccione R, Peyrin-Biroulet L, Beck K, Chaparro M, Gisbert JP, Dubcenco E, Klaff J, Naling G, Ford S, Remple V, Joshi N, Suravaram S, Duncan B, Wang Y, Wick-Urban B, Loftus EV.   +18 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Serum N-glycan profile shift during human ageing.

Experimental Gerontology, 2010
V. Vanhooren, S. Dewaele, C. Libert, S. Engelborghs, P. D. de Deyn, O. Toussaint, F. Debacq-Chainiaux, M. Poulain, Y. Glupczynski, C. Franceschi, Koos Jaspers, Ingrid van der Pluijm, J. Hoeijmakers, C. Chen   +13 more
semanticscholar   +1 more source