Results 161 to 170 of about 68,309 (304)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Advancing inclusion in sports for students with disability: A mixed-methods study on awareness and perspectives toward adaptive sports. [PDF]

PLoS One
Aldhahi MI, Bin Sheeha BH, Alothman NI, Basuodan RM, Alabdulwahab RA.   +4 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

In what ways is Goal Setting Unique in Adapted Sports Settings

Goal setting has the possibility to have a positive impact on athletes with disabilities in adapted sports. Although some athletes may find setting goals beneficial to help improve their performance.
Dubisar, Joseph E
core  

GPT-4 outperforms junior expert physical therapists in sports medicine rehabilitation: an evaluation of AI response quality and adaptiveness. [PDF]

Front Rehabil Sci
Hamrin Senorski E, Piussi R, Kaarre J, Feldt R, Webster KE, Hägglund M, Hamrin Senorski R, Högberg J, Yu Y, Samuelsson K.   +9 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The effects of adapted physical activity program, physical capacity and psychosocial behaviour on women with intellectual impairment.

, 2018
The aim of this study was to investigate the effects of adapted physical activity program, physical capacity and psychosocial behaviour on women with intellectual impairment.
Samulionytė, Deimantė,
core  

Adaptation to change: a meta-model of adaptation in sport

International Journal of Sport and Exercise Psychology, 2023
Roy David Samuel, Natalia Stambulova, Yair Galily, Gershon Tenenbaum   +3 more
openaire   +1 more source

Does a low-carbohydrate diet impede endurance sports performance? Debate Consensus. [PDF]

Am J Clin Nutr
Burke LM, Noakes TD.
europepmc   +1 more source