Results 121 to 130 of about 1,241,988 (301)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Adaptive Capacity as Cultural Practice

Ecology and Society, 2012
Benedict J. Colombi, Courtland L. Smith
doaj   +1 more source

Social networks and transformative behaviours in a grassland social‐ecological system

People and Nature
Social connections among individuals are essential components of social‐ecological systems (SESs), enabling people to take actions to more effectively adapt or transform in response to widespread social‐ecological change.
Holly K. Nesbitt, Alexander L. Metcalf, Theresa M. Floyd, Daniel R. Uden, Brian C. Chaffin, Sabrina Gulab, Simanti Banerjee, Sechindra Vallury, Samantha L. Hamlin, Elizabeth Covelli Metcalf, Dillon T. Fogarty, Dirac Twidwell, Craig R. Allen   +12 more
doaj   +1 more source

Price volatility in fish food systems: spatial arbitrage as an adaptive strategy for small-scale fish traders

Ecology and Society
Anthropogenic stressors such as land-use change, habitat degradation, and climate change stress inland fish populations globally. Such ecological disturbances can affect actors throughout the social-ecological system by contributing to uncertainty in ...
Emma D Rice, Abigail E. Bennett, Martin D Smith, Lenis Saweda O Liverpool-Tasie, Samson P Katengeza, Dana M Infante, David L Tschirley   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Institutions for Climate Change : A Method to assess the Inherent Characteristics of Institutions to enable the Adaptive Capacity of Society [PDF]

This paper addresses the question: How can the inherent characteristics of institutions to stimulate the adaptive capacity of society to climate change from local through to national level be assessed?
Brink, M.A., van den, Gupta, J., Jong, P., Klostermann, J.E.M., Meijerink, S., Nooteboom, S.G., Termeer, C.J.A.M.   +6 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Theatre practitioners and organisational adaptive capacity in disaster response. [PDF]

J Perioper Pract, 2023
Klunder-Rosser J.
europepmc   +1 more source