Results 141 to 150 of about 1,241,988 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Capacity to Promote Adaptation [PDF]

, 2020
William C. Clark, Alicia G. Harley
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Editorial: Diversifying Farming Systems for Adaptive Capacity

Frontiers in Sustainable Food Systems, 2021
Margiana Petersen-Rockney, Timothy Bowles, Selena Ahmed, Patrick Baur   +3 more
doaj   +1 more source

Understanding the adaptive capacity of Australian small-to-medium enterprises to climate change and variability [PDF]

Small-to-medium enterprises (SMEs) comprise 96 per cent of all private businesses in Australia. The SME sector is the economy’s largest employer and the largest contributor to GDP.
Janina Murta, Natasha Kuruppu, Pierre Mukheibir   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Editorial: Climate change and adaptive capacity building

Frontiers in Environmental Science, 2023
Wei Shui, Wanyu Shui, Junyu Qi, Haijun Deng, Shaoquan Liu   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Threat Perception and Adaptive Capacity of Natural World Heritage Site Management. [PDF]

Environ Manage, 2023
Falk MT, Hagsten E.
europepmc   +1 more source

Kernel-based nonlinear beamforming construction using orthogonal forward selection with Fisher ratio class separability measure

, 2004
This letter shows that the wireless communication system capacity is greatly enhanced by employing nonlinear beamforming and the optimal Bayesian beamformer outperforms the standard linear beamformer significantly in terms of a reduced bit error rate, at
Chen, S., Hanzo, L., Wolfgang, A.
core   +1 more source