Results 101 to 110 of about 60,047 (288)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

An analysis of the adaptive cluster sampling design with rare plant point distributions

, 2009
Thesis (M.A.)--Humboldt State University, Biological Sciences, 2009A sampling design that can provide estimates of abundance with low variance is very valuable to biologists working with limited budgets and time.
Tout, Jeremy
core   +2 more sources

The Effect of Cognitive and Cognitive–Meta Cognitive Education Strategies on Problem Solving Ability and Adaptive Behavior of Mentally Retarded Students [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī, 2013
The present study aims at investigating the effects of cognitive and cognitive–meta cognitive education strategies on problem solving ability and adaptive behavior of mentally retarded students in junior professional schools.
Alireza Mohammadi Arya, Maryam Seyf Naraqi, Ali Delavar, Esmail Sa’dipour   +3 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Applications in adaptive cluster sampling of Gulf of Alaska rockfish [PDF]

, 2003
Adaptive cluster sampling (ACS) has been the subject of many publications about sampling aggregated populations. Choosing the criterion value that invokes ACS remains problematic.
Clausen, David, Quinn II, Terrance J., Lunsford, Chris, Hanselman, Dana H., Heifetz, Jonathan   +4 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A scalable load balancing strategy based on distributed server cluster

Dianxin kexue, 2017
A distributed database load balancing algorithm based on software defined networking was proposed,which separated the data,control and application to calculate the actual load of a single server in the server cluster.By querying the streams sampling ...
Qiao SUN, Buqiao DENG, Zhiqiang WANG, Xubin PEI   +3 more
doaj   +2 more sources

Variance estimation for adaptive cluster sampling with a single primary unit and the partially systematic adaptive cluster sampling

, 2009
Thesis (Ph.D. (Statistics))--National Institute of Development Administration, 2009Two topics are investigated in this dissertation. The first concerns variance estimation when a single primary sampling unit is selected. Two new bias variance estimators,
Urairat Netharn
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source