Results 131 to 140 of about 2,982,181 (249)

Manual and automatic authoring for adaptive hypermedia [PDF]

open access: yes
Adaptive Hypermedia allows online content to be tailored specifically to the needs of the user. This is particularly valuable in educational systems, where a student might benefit from a learning experience which only displays (or recommends) content ...
Foss, Jonathan G. K.
core  

Resilience Measurement and Evolution Characteristics of Resource-Based Cities in Heilongjiang Province Based on Adaptive Cycle Framework from 2010 to 2019

open access: yesFengjing Yuanlin
ObjectiveResource-based cities in Heilongjiang Province have encountered a series of challenges during their transformation, including resource depletion, industrial decline, environmental pollution, and population outflow.
Zhuolin TAN, Ming LU, Wei DONG, Yu DONG
doaj   +1 more source

Parametric Cycle Analysis of Adaptive Cycle Engine [PDF]

open access: yes2018 Joint Propulsion Conference, 2018
Harinkumar R. Patel, Donald Wilson
openaire   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Management, storage and disposal of nuclear and radioactive waste (Issues Paper Four)

open access: yes, 2015
This Nuclear Fuel Cycle Royal Commission Issues Paper looks at the possibility of managing, storing and disposing of nuclear and radioactive waste in South Australia, and examines the risks and opportunities of doing ...
Nuclear Fuel Cycle Royal Commission
core  

Adaptive Gibbs samplers [PDF]

open access: yes, 2010
We consider various versions of adaptive Gibbs and Metropolis- within-Gibbs samplers, which update their selection probabilities (and perhaps also their proposal distributions) on the fly during a run, by learning as they go in an attempt to optimise
Rosenthal, Jeffrey S. (Jeffrey Seth)   +1 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Evaluating adaptive authoring of adaptive hypermedia [PDF]

open access: yes, 2007
Now-a-days a large amount of research exists into the design and implementation of adaptive systems, but still, a lot less targets the complex task of authoring of such systems, or their evaluation.
Hendrix, Maurice, Cristea, Alexandra I.
core  

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