Results 121 to 130 of about 2,040,374 (260)
Political Business Cycles through Lobbying [PDF]
In this paper we build a framework where the interplay between the lobby power of special interest groups and the voting power of the majority of the population leads to political business cycles.
Marco Bonomo, Cristina Terra
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
ECONOMICAL VERSUS POLITICAL CYCLES IN AN IBERIAN MANUFACTURING SECTOR [PDF]
The paper discusses several questions related to the economic cycles, from the scientific methodological approach to isolate the economic cycles, to an empirical application using data of the Portuguese industrial sector, passing by the identification of
jose ramos pires manso
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Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Modelling and control of adaptive mechanical structures Proceedings
, 1998 Adaptive structures (smart structures) are autonomous structural systems with integrated multifunctional smart materials as actuators and sensors, connected by a control system, to facilitate adaptation to changing environmental conditions (e.g.
Gabbert, U. (comp.) +1 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Temporal aggregation in political budget cycles [PDF]
While existing cross-country studies on political budget cycles rely on annual data, we build a panel with quarterly and monthly data from Latin American and OECD countries over the 1980-2005 period.
Daniel Lema, Jorge M. Streb
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Adaptive Distributed Architectural Systems
, 2012 Artificial Intelligence has a long and rich history in the field of architecture. Building upon this history, we clarify the term “adaptive” and its use within the field.
A. Schlueter, Z. Nagy, D. Rossi
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