Results 81 to 90 of about 1,720,153 (304)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Design and Study of LoRa-Based IIoT Network for Underground Coal Mine Environment

IEEE Access
The paper presents a novel LoRa-based IIoT system for monitoring the underground coal mine environment. Additionally, a new adaptive data rate algorithm for mesh network topology is proposed to optimize the data rate and maximize the coverage distance ...
Ankita Ray Chowdhury, Saikat Chandra Bakshi, Ankita Pramanik, Gopal Chandra Roy   +3 more
doaj   +1 more source

Development and performance evaluation of a novel knowledge guided artificial neural network (KGANN) model for exchange rate prediction

Journal of King Saud University: Computer and Information Sciences, 2015
This paper presents a new adaptive forecasting model using a knowledge guided artificial neural network (KGANN) structure for efficient prediction of exchange rate. The new structure has two parallel systems. The first system is a least mean square (LMS)
Pradyot Ranjan Jena, Ritanjali Majhi, Babita Majhi   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Estimating the Rate Constant from Biosensor Data via an Adaptive Variational Bayesian Approach [PDF]

, 2019
Y. Zhang, Zengyu Yao, Patrik Forssén, Torgny Fornstedt   +3 more
openalex   +3 more sources

Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals.

PLoS Genetics, 2020
Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with species effective ...
Marjolaine Rousselle, Paul Simion, Marie-Ka Tilak, Emeric Figuet, Benoit Nabholz, Nicolas Galtier   +5 more
doaj   +1 more source

Adaptive Rate-optimal Detection of Small Autocorrelation Coefficients [PDF]

A new test is proposed for the null of absence of serial correlation. The test uses a data-driven smoothing parameter. The resulting test statistic has a standard limit distribution under the null.
Alain Guay, Emmanuel Guerre, Štěpána Lazarová   +2 more
core  

Data-adaptive smoothing for optimal-rate estimation of possibly non-regular parameters [PDF]

, 2017
Aurélien Bibaut, Mark J. van der Laan
openalex   +2 more sources