Results 161 to 170 of about 1,920,879 (284)

Adaptive designs for bioequivalence trails

, 2007
In recent years, there has been a growing interest within the medical research community in the application of adaptive designs in drug development. One potential application of adaptive designs is for bioequivalence trials, as they provide a means for ...
Montague, Timothy H
core  

Exploring Bayesian adaptive designs in multi-arm randomized controlled trials with a patient preference arm. [PDF]

J Biopharm Stat
Brown AR, Gajewski BJ, Mudaranthakam DP, Carlson SE, Dutta S, Christifano DN.   +5 more
europepmc   +1 more source

Adaptive Designs: Lessons for Inflammatory Bowel Disease Trials. [PDF]

J Clin Med, 2020
D'Amico F, Danese S, Peyrin-Biroulet L.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Adaptive designs in randomized clinical trials: reanalysis of the HOVON87/NMSG18 multiple myeloma trial. [PDF]

EClinicalMedicine
Seefat MR, van der Maas NG, Nasserinejad K, van der Holt B, Waage A, Mellqvist UH, Vangsted AJ, Smit AJT, Smits F, Ypma PF, van de Donk NWCJ, Blommestein HM, Cornelissen JJ, Cucchi DGJ, Zweegman S, Versluis J.   +15 more
europepmc   +1 more source

Clinical Trials Impacted by the COVID-19 Pandemic: Adaptive Designs to the Rescue? [PDF]

Stat Biopharm Res, 2020
Kunz CU, Jörgens S, Bretz F, Stallard N, Van Lancker K, Xi D, Zohar S, Gerlinger C, Friede T.   +8 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Adaptive beamforming assisted receiver

, 2007
Adaptive beamforming is capable of separating user signals transmitted on the same carrier frequency, and thus provides a practical means of supporting multiusers in a space-division multiple-access scenario.
Sheng Chen, Chen, Sheng
core  

Insight and benefits from vaccine clinical trials with adaptive designs: a scoping review. [PDF]

Transl Clin Pharmacol
García-Sierra AM, Urbina Moreno LA, Flanigan C, Jimeno J, Rivera-Pinzón DC.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source