Results 241 to 250 of about 1,011,945 (297)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Adaptive evolution of Pseudomonas aeruginosa ST299 population colonizing a hospital copper water network over a 2.5-year period. [PDF]

Microb Genom
Virieux-Petit M, Aujoulat F, Dupont C, Marchandin H, Jumas-Bilak E, Romano-Bertrand S.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Organelle genomes reveal adaptive evolution and phylogenetic position of the endangered <i>Primula mallophylla</i>. [PDF]

Front Plant Sci
Li W, Wang L, Zuo Y, Zhang H, Zhang X, Yang L, Zhang J, Zheng F, Deng H.   +8 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Adaptive Evolution and Distinct Mutation Signatures of Full-Length HBV Quasispecies in HBeAg-Negative Chronic Hepatitis B. [PDF]

Microbiologyopen
Wu C, Liu F, Li X, Li X, Li H, Zhang S, Yan X, Zhou T, Wei J.   +8 more
europepmc   +1 more source

Truncation of <i>LPD1</i> promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast. [PDF]

Synth Syst Biotechnol
Qin L, He S, Yuan D, Pan Y, Yan Z, Huang M.   +5 more
europepmc   +1 more source