Results 251 to 260 of about 277,643 (313)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Characterization of adaptive evolution strains for the development of triclosan resistance in <i>Agrobacterium tumefaciens</i> C58. [PDF]

Appl Environ Microbiol
Tasnawijitwong N, Nontaleerak B, Sirikanchana K, Satayavivad J, Sukchawalit R, Mongkolsuk S.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Adaptive evolution of <i>Pseudomonas putida</i> in the presence of fluoride exposes novel functions of a benzoate transporter. [PDF]

J Bacteriol
Ets L, Ilves H, Juhe L, Ilmjärv T, Puiggené Ò, Nikel PI, Kivisaar M.   +6 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Adaptive evolution of <i>Candida maltosa</i> improves the bioconversion of depolymerized plastic feedstock by targeting biosurfactant production. [PDF]

Appl Environ Microbiol
Rodriguez-Ocasio E, Noroozi K, Khalid A, Brown J, Brown RC, Blenner MA, Jarboe LR.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Distinct infectivity, pathogenicity, and adaptive evolution of clade 2.3.4.4 H5N2 avian influenza viruses in chickens in Taiwan. [PDF]

Poult Sci
Chen LH, Lin YJ, Liu YP, Li WC, Tu YC, Hu SC, Hsu WC, Chen YW, Lee F, Ou SC, Deng MC, Hsu WL.   +11 more
europepmc   +1 more source

Neighborhood Adaptive Differential Evolution

Proceedings of the Genetic and Evolutionary Computation Conference Companion
openaire   +2 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source