Results 31 to 40 of about 1,628,090 (248)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Two-dimensional Adaptive Analysis Based on Arbitrary Meshes and Its Optimization [PDF]
长江科学院院报[Objective] This study aims to optimize the two-dimensional adaptive analysis strategy of the independent cover-based manifold method, focusing on addressing its deficiencies in error control and mesh distribution, thereby significantly enhancing ...
SONG Wen-shuo, SU Hai-dong, XIE Zhi-qiang
doaj +1 more source
Adaptive Semi-Structured Mesh Refinement Techniques for the Finite Element Method
Applied Sciences, 2021 The adaptive mesh techniques applied to the Finite Element Method have continuously been an active research line. However, these techniques are usually applied to tetrahedra. Here, we use the triangular prismatic element as the discretization shape for a
Adrian Amor-Martin +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Efficient Adaptive Mesh Refinement Architecture on Mobile Terminals
工程科学与技术, 2014 :For the problem that mobile terminals can hardly show the three-dimensional models fast and realistically,the adaptive mesh refinement architecture adapting to mobile terminals was proposed.The general adaptive refinement template was designed to reduce
聂俊岚 +3 more
doaj
Application of the fully automatic hp-adaptive FEM to elastic-plastic problems [PDF]
Computer Methods in Materials Science, 2014 The hp-adaptive mesh refinement is a technique that for linear problems proved to deliver a fast, predicted by theory, exponential convergence. We have applied this approach to elastic-plastic problems modeled by associative constitutive law with the ...
Marta Oleksy, Witold Cecot
doaj +1 more source
Advanced Engineering Materials, EarlyView.A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares +3 more
wiley +1 more source