Results 81 to 90 of about 6,023,413 (342)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Adaptive Protection Scheme for Active Distribution Networks Under Two-Phase Short-Circuit Faults Based on Integrated Sequence Components

Energies
The widespread integration of inverter-based distributed generators (IIDGs) severely limits the adaptability of conventional three-step overcurrent protection in distribution networks (DNs).
Shi Su, Yuan Li, Xuehao He, Faping Hu, Yingwei Guo, Jialin Liu, Xiaolong Chen, Botong Li, Jing Zhang   +8 more
doaj   +1 more source

Spatially explicit groundwater vulnerability assessment to support the implementation of the Water Framework Directive – a practical approach with stakeholders [PDF]

, 2008
The main objective of the study presented in this paper was to develop an evaluation scheme which is suitable for spatially explicit groundwater vulnerability assessment according to the Water Framework Directive (WFD).
Berkhoff, Karin
core  

An Adaptive Protection Technique for Smart Distribution Network

, 2020
The future distribution networks (DNs), commonly known as the smart grid is expected to be reliable, efficient, and can accommodate renewable energy resources.
A. Shobole, M. Baysal, Mohammed Wadi, Mehmet Rida Tur   +3 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Method of dynamic trust assessment in Zero Trust Architecture based on explainable artificial intelligence

Ìнформаційні технології та компʼютерна інженерія
The transformation of contemporary corporate IT infrastructures has rendered conventional cybersecurity models ineffective, prompting a shift to the Zero Trust Architecture (ZTA); however, its practical implementation is complicated by a rigid reliance ...
A. Palamarchuk
doaj   +1 more source

MicroRNA regulation of CD8+ T cell responses. [PDF]

, 2019
MicroRNAs (miRNAs) are a class of short noncoding RNAs that play critical roles in the regulation of a broad range of biological processes. Like transcription factors, miRNAs exert their effects by modulating the expression of networks of genes that ...
Ansel, K Mark, Gagnon, John D
core   +1 more source