Results 61 to 70 of about 126,743 (307)

Metaphors as surrogate variables. The case of adaptive radiation [PDF]

, 2011
We develop a new metaphor account where metaphors become surrogate variables for different but related phenomena. As we will argue, subrogation is the result of the interplay between the things inspired by the metaphor and the empirical dynamics that ...
Olson, Mark E., Arroyo-Santos, Alfonso
core  

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Efficient computation of spinning modal radiation through an engine bypass duct

, 2008
The aim of this work is to accurately and efficiently predict sound radiation out of a duct with flow. The sound propagation inside a generic engine bypass duct, refractions by the shear layer of the exhaust flow, and propagation in the near field are ...
Zhang, Xin, Chen, Xiaoxian, Ma, Zhaokai, Huang, Xun   +3 more
core   +1 more source

Optimization of treatment planning workflow and tumor coverage during daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT) of pancreatic cancer [PDF]

, 2018
BACKGROUND: To simplify the adaptive treatment planning workflow while achieving the optimal tumor-dose coverage in pancreatic cancer patients undergoing daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT).
김진성
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Anemonefishes: A model system for evolutionary genomics [version 2; peer review: 2 approved]

F1000Research, 2023
Anemonefishes are an iconic group of coral reef fish particularly known for their mutualistic relationship with sea anemones. This mutualism is especially intriguing as it likely prompted the rapid diversification of anemonefish.
Vincent Laudet, Marcela Herrera, Timothy Ravasi   +2 more
doaj   +1 more source

Adaptive Radiation for Lung Cancer [PDF]

Journal of Oncology, 2011
The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such as four-dimensional (4D) image-based motion management, daily on-board imaging and adaptive radiotherapy based on volumetric images over the course of ...
Gomez, Daniel R., Chang, Joe Y.
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Dynamic patterns of adaptive radiation [PDF]

Proceedings of the National Academy of Sciences, 2005
Adaptive radiation is defined as the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. When it occurs, adaptive radiation typically follows the colonization of a new environment or the establishment of a “key innovation,” which opens new ecological niches and/or new paths for evolution.
Sergey, Gavrilets, Aaron, Vose
openaire   +2 more sources

Heterogeneous Adaptive Trajectories of Small Populations on Complex Fitness Landscapes

, 2008
Background Small populations are thought to be adaptively handicapped, not only because they suffer more from deleterious mutations but also because they have limited access to new beneficial mutations, particularly those conferring large benefits ...
J Arjan G M de Visser, Handel, Andreas, de Visser, J. Arjan G M, Habets, M.G.J.L., Michelle G J L Habets, Andreas Handel, Handel, A., Visser, J.A.G.M., de, de Visser, J.A.G.M., Habets, Michelle G J L, Daniel E Rozen, Rozen, Daniel E., Rozen, D.E.   +12 more
core   +1 more source