Results 71 to 80 of about 371,826 (345)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
A general hybrid radiation transport scheme for star formation simulations on an adaptive grid [PDF]
, 2014 Radiation feedback plays a crucial role in the process of star formation. In order to simulate the thermodynamic evolution of disks, filaments, and the molecular gas surrounding clusters of young stars, we require an efficient and accurate method for ...
Banerjee, Robi +5 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
An Improved NSGA-II and its Application for Reconfigurable Pixel Antenna Design [PDF]
, 2014 Based on the elitist non-dominated sorting genetic algorithm (NSGA-II) for multi-objective optimization problems, an improved scheme with self-adaptive crossover and mutation operators is proposed to obtain good optimization performance in this paper ...
Chen, H. +3 more
core +1 more source
Resolving the Formation of Protogalaxies. III. Feedback from the First Stars [PDF]
, 2007 The first stars form in dark matter halos of masses ~10^6 M_sun as suggested by an increasing number of numerical simulations. Radiation feedback from these stars expels most of the gas from their shallow potential well of their surrounding dark matter ...
de Blok W. J. G. +7 more
core +2 more sources
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Burrowing activity of coconut rhinoceros beetle on Guam cycads
Communicative & Integrative Biology, 2020 Guam’s established population of non-native coconut rhinoceros beetle (CRB, Oryctes rhinoceros L.) began creating burrows in stem apices of several cycad species in a managed garden. We conducted an island-wide survey to determine the spatial patterns of
Thomas E. Marler +2 more
doaj +1 more source
Frontiers in Plant Science, 2020 Dendroseris D. Don comprises 11 species endemic to the Juan Fernández islands in Chile. They demonstrate spectacular and unusual growth forms of rosette trees with extremely variable morphology and occupy wide ecological ranges on the islands.
Myong-Suk Cho +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Ecology and Evolution, 2020 Food resource specialization within novel environments is considered a common axis of diversification in adaptive radiations. Feeding specializations are often coupled with striking morphological adaptations and exemplify the relation between morphology ...
Lukas Widmer +3 more
doaj +1 more source