Results 181 to 190 of about 12,788,874 (304)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Adaptive Sampling Framework for Imbalanced DDoS Traffic Classification. [PDF]

Sensors (Basel)
Kim H, Ham D, Moon KS.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Long read nanopore DNA sequencing with adaptive sampling to identify tyrosine kinase fusion genes. [PDF]

Leukemia
Salmon M, Naumann N, Rinke J, Meggendorfer M, Radia D, Pomfret M, Ernst T, Hochhaus A, Reiter A, Tapper WJ, White H, Cross NCP.   +11 more
europepmc   +1 more source

Nanopore adaptive sampling enriches for antimicrobial resistance genes in microbial communities. [PDF]

GigaByte, 2023
Wrenn DC, Drown DM.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Proof-of-principle: nanopore adaptive sampling enables full blood group genome analysis and resolution of hybrid alleles. [PDF]

Blood Adv
Gueuning M, Thun GA, Koller S, Sigurdardottir S, Trost N, Wagner L, Mayer B, Engström C, Mattle-Greminger MP, Meyer S.   +9 more
europepmc   +1 more source

Targeted haplotyping in pharmacogenomics using Oxford Nanopore Technologies' adaptive sampling. [PDF]

Front Pharmacol, 2023
Deserranno K, Tilleman L, Rubben K, Deforce D, Van Nieuwerburgh F.   +4 more
europepmc   +1 more source

ADASYN: Adaptive synthetic sampling approach for imbalanced learning

IEEE World Congress on Computational Intelligence, 2008
Haibo He, Yang Bai, E. A. Garcia, Shutao Li   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source