Results 161 to 170 of about 3,594,430 (292)

Adaptive sampling in the Philippine Sea using autonomous profiling floats and FloatCast. [PDF]

Front Robot AI
Tolone JR, Harrison TW, Szuts ZB, Paley DA.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Flexible and rapid validation of structural variation using adaptive sampling. [PDF]

Eur J Hum Genet
Paivandy A, Lenner F, Eisfeldt J, Jonson T, Ehrencrona H, Lindstrand A, Scherer SW, Feuk L.   +7 more
europepmc   +1 more source

Search and Retrieval]: Retrieval models. General Terms: Algorithms.

, 2008
We study how to answer aggregation queries over hierarchical Web sites using adaptive ...
Adaptive Sampling, Chen Li, Paraskevas V. Lekeas, Foto N. Afrati   +3 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Application of nanopore adaptive sampling for metagenomic detection of tick-borne RNA viruses. [PDF]

Sci Rep
Byun HR, Ji SR, Frank LE, Kipp EJ, Larsen PA, Chae JS.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Interpretable ROI Identification in Brain Image Analysis: Overcoming CNN Black Box Challenges With Kriging-Enhanced Adaptive Sampling. [PDF]

Stat Med
Lee H, Yu J, Park S, Sternberg Z.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Detection of heteroresistance in Mycobacterium tuberculosis using nanopore-based amplicon sequencing and adaptive sampling. [PDF]

Sci Rep
Taquiri-Díaz DA, Ramos-Lette DM, Romero-Rodriguez OA, Barrios-Tapia CE, Apaza-Quiroz CA, Hurtado B, Avellaneda-Menéndez PJD, Orellana-Montes J, Huaman S, Perez-Martinez JL, Vallejos-Sanchez K, León C, Gilman RH, Grandjean L, Zimic M, Sheen P.   +15 more
europepmc   +1 more source