Results 61 to 70 of about 486,331 (269)

Resilience Factors of Ukrainian Micro, Small, and Medium-Sized Business

Economies
Nowadays, businesses in Ukraine face new challenges that the world has never experienced before. Earlier, during the war, countries had to curtail their economic activities, everything operated for the sake of military needs.
Andrii Dligach, Andriy Stavytskyy
doaj   +1 more source

Caspian Sea: Embracing change for a sustainable future.. [PDF]

Caspian Journal of Environmental Sciences
The Caspian Sea, the world's largest inland body of water, has long experienced significant water-level fluctuations due mainly to natural factors, with additional impacts from human activities.
Hamid A. K. Lahijani, Peygham Ghaffari, Abdolmajid Naderi Beni   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Understanding quality of life in bipolar disorder: associated factors and coping strategies

Frontiers in Psychology
BackgroundBipolar disorder (BD) is a chronic mental health condition that significantly affects an individual's quality of life (QoL). While previous research has primarily concentrated on the clinical aspects of BD, there is increasing interest in ...
Hessah Alzahrani
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Response of the Functional Traits of Phragmites australis and Bolboschoenus planiculmis to Water and Saline–Alkaline Stresses

Plants
Soil saline–alkaline stress and water stress, exacerbated by anthropogenic activities and climate change, are major drivers of wetland vegetation degradation, severely affecting the function of wetland ecosystems. In this study, we conducted a simulation
Lili Yang, Yanjing Lou, Zhanhui Tang
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Japan shellfish farmer perceptions of ocean acidification, adaptive strategies and comparison with global shellfish farmers

Frontiers in Marine Science
Ocean acidification (OA) poses significant threats to shellfish aquaculture. Although governments and organizations around the globe are taking actions to mitigate the impacts of OA, few studies directly report shellfish farmer perceptions of OA and ...
Yumeng Pang, Yumeng Pang, Kristen Marie Green, Yulan Kim, Yulan Kim, Ryuji Hamanoue, Keita Furukawa, Takehiro Tanaka, Yoshitaka Ota   +8 more
doaj   +1 more source