Results 81 to 90 of about 487,457 (268)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Instructional Leadership Practices of School Principals in Remote Areas: A Multi-Site Study in South Central Timor Regency

Sociological Education
Principal learning leadership is an important factor in improving the quality of education, but its implementation in remote areas still faces various structural and resource limitations.
Arifin, I Nyoman Jampel, Dewa Bagus Sanjaya, I Wayan Widiana   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Adaptive instructional leadership in geographically isolated schools: practices, challenges, and strategies of elementary school principals in Tawi-Tawi

Frontiers in Education
IntroductionInstructional leadership is central to school improvement, yet it remains underexplored in geographically isolated schools where principals face chronic resource scarcity, weak infrastructure, and cultural isolation.
Solita Utoh-Asim Jemsy, Nilo Jayoma Castulo, Almira Amilbangsa Hadji, Zeda Sangkula, Russel Bradecina Reyes, Pattra Sakib Ugis, Shernaiza Hajad, Nadzmin Jalani Dugasan, Kharsum Mohammad, Radzmalyn Abdurahman Akmad, Radzmal Soriano Abbani, Al-Sabrie Sahijuan, Ajilma Majid Tambihasan, Alsadjaik Ytang Sabdul, Darwisa Sali Ondo   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Within-host adaptation mutations associated with persistent colonization of Pseudomonas aeruginosa in a silicosis patient

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is a notorious opportunistic pathogen that causes life-threatening infections in immunocompromised individuals. In this study, we isolated two mucoid imipenem-resistant P.
Furong Zhang, Lvxin Qian, Yi Yan, Qiuling Wan, Luhua Zhang, Ying Li   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Social Resilience and Adaptive Strategies of Female-Headed Households in Indonesia

ASEAN Social Work Journal
Female-headed households (FHHs), locally referred to as Perempuan Kepala Keluarga (PEKKA), represent a socially vulnerable group facing multiple and intersecting challenges in simultaneously managing productive and reproductive roles.
Tuti Kartika, Bambang Rustanto, Aryohaji Istyawan, Rajendra Panggita Vasthu   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source