Results 81 to 90 of about 6,146,821 (306)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Understanding quality of life in bipolar disorder: associated factors and coping strategies
Frontiers in PsychologyBackgroundBipolar disorder (BD) is a chronic mental health condition that significantly affects an individual's quality of life (QoL). While previous research has primarily concentrated on the clinical aspects of BD, there is increasing interest in ...
Hessah Alzahrani
doaj +1 more source
Supporting authoring of adaptive hypermedia [PDF]
It is well-known that students benefit from personalised attention. However, frequently teachers are unable to provide this, most often due to time constraints.
Hendrix, Maurice
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Where do adaptive planning strategies come from?
, 2022 Data and code to the submission "Where do adaptive planning strategies come from?
Ruiqi He
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PlantsSoil saline–alkaline stress and water stress, exacerbated by anthropogenic activities and climate change, are major drivers of wetland vegetation degradation, severely affecting the function of wetland ecosystems. In this study, we conducted a simulation
Lili Yang, Yanjing Lou, Zhanhui Tang
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Frontiers in Marine ScienceOcean acidification (OA) poses significant threats to shellfish aquaculture. Although governments and organizations around the globe are taking actions to mitigate the impacts of OA, few studies directly report shellfish farmer perceptions of OA and ...
Yumeng Pang +8 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source