Results 101 to 110 of about 6,146,821 (306)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Water Systems Design: Connecting and Developing Methods for the Value Case Approach

Blue Papers
Water uses and practices are typically dissociated and considered separately: drinking water, sewage systems and shipping are often treated as distinct systems.
Carola Hein
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Toward a Value Case Approach for Designing Sustainable Water Systems

Blue Papers
Designing water systems – interconnected networks of water-related structures and practices – is not only a matter of technology and economics, but also of history, institutions and culture.
Carola Hein
doaj   +1 more source

Learning algorithms for adaptive digital filtering [PDF]

, 1993
In this thesis, we consider the problem of parameter optimisation in adaptive digital filtering. Adaptive digital filtering can be accomplished using both Finite Impulse Response (FIR) filters and Infinite Impulse Response Filters (IIR) filters. Adaptive
Nambiar, Raghu
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Within-host adaptation mutations associated with persistent colonization of Pseudomonas aeruginosa in a silicosis patient

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is a notorious opportunistic pathogen that causes life-threatening infections in immunocompromised individuals. In this study, we isolated two mucoid imipenem-resistant P.
Furong Zhang, Lvxin Qian, Yi Yan, Qiuling Wan, Luhua Zhang, Ying Li   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Adaptive instructional leadership in geographically isolated schools: practices, challenges, and strategies of elementary school principals in Tawi-Tawi

Frontiers in Education
IntroductionInstructional leadership is central to school improvement, yet it remains underexplored in geographically isolated schools where principals face chronic resource scarcity, weak infrastructure, and cultural isolation.
Solita Utoh-Asim Jemsy, Nilo Jayoma Castulo, Almira Amilbangsa Hadji, Zeda Sangkula, Russel Bradecina Reyes, Pattra Sakib Ugis, Shernaiza Hajad, Nadzmin Jalani Dugasan, Kharsum Mohammad, Radzmalyn Abdurahman Akmad, Radzmal Soriano Abbani, Al-Sabrie Sahijuan, Ajilma Majid Tambihasan, Alsadjaik Ytang Sabdul, Darwisa Sali Ondo   +14 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source