Results 61 to 70 of about 4,949,103 (256)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Adaptive planar structures [PDF]

open access: yes, 2010
p. 2405-2417Panes and shells as only in-plane loaded structural elements play an important role in lightweight structures. However their great bearing capacity will be reduced significantly when their homogeneous stress distribution is disturbed. These
WEILANDT, Agnes
core  

Variable-stiffness skin concept for camber-morphing airfoils

open access: yes, 2013
Morphing airfoils promise advances in performance and efficiency when compared to conventional designs. However, the conflict of requirements between compliance and stiffness, that is characteristic of shape-adaptable structures, often leads to ...
Ermanni, Paolo (author)   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Optimizing stability bounds of finite-precision PID controller structures [PDF]

open access: yes, 1999
The paper investigates a recently derived lower bound stability measure for sampled-data controller structures subject to finite-word-length (FWL) constraints. The optimal realization of the digital PID controller with FWL considerations is formulated as
J. Wu   +8 more
core   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Vibration control of MRE isolator-embedded smart building using genetic algorithm

open access: yes, 2019
This study developed the adaptive genetic algorithm (GA) for vibration control of building structures subjected to ambient hazard excitations. An innovative smart building system was designed based on magnetorheological elastomer (MRE) isolators under ...
Li, Yancheng   +5 more
core  

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