Results 101 to 110 of about 290,952 (260)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Non-contact radar-based HRV monitoring method using adaptive cycle segmentation and peak extraction

Journal of Measurement Science and Instrumentation
Heart rate variability (HRV), as a key indicator for evaluating autonomic nervous system function, has significant value in areas such as cardiovascular disease screening and emotion monitoring.
GAO Yixuan, ZHU Xinxing, LI Mingchao, WU Enkang, GU Xiaofeng, WANG Cong, YU Tian, LIANG Junge   +7 more
doaj  

Properties of the SURE Estimates When Using Continuous Thresholding Functions for Wavelet Shrinkage

Mathematics
Wavelet analysis algorithms in combination with thresholding procedures are widely used in nonparametric regression problems when estimating a signal function from noisy data.
Alexey Kudryavtsev, Oleg Shestakov
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Group Search Algorithm for Optimal Scheduling of Cascade Hydropower Stations

Renmin Zhujiang
The coronavirus herd immunity optimizer (CHIO) algorithm was introduced to address the optimal scheduling problem of cascade hydropower plants, and an improved algorithm called LCHIO was proposed.
WANG Kechao, CAI Ruoyi, SHEN Jianjian
doaj  

A Study of Adaptive Threshold Based on the Reconstruction Model for Marine Systems and Their Equipment Failure Warning

Journal of Marine Science and Engineering
To achieve the failure warning of marine systems and their equipment (MSAE), the threshold is one of the most prominent issues that should be solved first.
Xuxu Duan, Zeyu Gao, Zhenxing Qiao, Taili Du, Yongjiu Zou, Peng Zhang, Yuewen Zhang, Peiting Sun   +7 more
doaj   +1 more source

Coronary Artery Lumen Segmentation Using Location-Adaptive Threshold in Coronary Computed Tomographic Angiography: A Proof-of-Concept. [PDF]

Korean J Radiol, 2021
Shin CI, Park SJ, Kim JH, Yoon YE, Park EA, Koo BK, Lee W.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source