Results 121 to 130 of about 880,054 (288)

Adaptive threshold-based alarm strategies for continuous vital signs monitoring. [PDF]

J Clin Monit Comput, 2022
van Rossum MC, Vlaskamp LB, Posthuma LM, Visscher MJ, Breteler MJM, Hermens HJ, Kalkman CJ, Preckel B.   +7 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

FAST Algorithm for Accurate Corner Points Detection of Section Steel Based on Adaptive Threshold

Shanghai Jiaotong Daxue xuebao
The on-line flatness detection of section steel based on machine vision is a key technical problem for quickly and accurately extracting key corner points from section steel images to enable accurate detection.
BAO Jiahan, SUN Deshang, HUANG Jianzhong, HU Zheng
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Coronary Artery Lumen Segmentation Using Location-Adaptive Threshold in Coronary Computed Tomographic Angiography: A Proof-of-Concept. [PDF]

Korean J Radiol, 2021
Shin CI, Park SJ, Kim JH, Yoon YE, Park EA, Koo BK, Lee W.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Properties of the SURE Estimates When Using Continuous Thresholding Functions for Wavelet Shrinkage

Mathematics
Wavelet analysis algorithms in combination with thresholding procedures are widely used in nonparametric regression problems when estimating a signal function from noisy data.
Alexey Kudryavtsev, Oleg Shestakov
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Study of Adaptive Threshold Based on the Reconstruction Model for Marine Systems and Their Equipment Failure Warning

Journal of Marine Science and Engineering
To achieve the failure warning of marine systems and their equipment (MSAE), the threshold is one of the most prominent issues that should be solved first.
Xuxu Duan, Zeyu Gao, Zhenxing Qiao, Taili Du, Yongjiu Zou, Peng Zhang, Yuewen Zhang, Peiting Sun   +7 more
doaj   +1 more source