Results 71 to 80 of about 870,231 (290)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Online Spectrum Prediction With Adaptive Threshold Quantization
IEEE Access, 2019 In this paper, we explore the spectrum inference to achieve the spectrum occupancy in advance through analyzing the historical spectrum. We have conceived an offline-online cooperative framework.
Haoyu Li +4 more
doaj +1 more source
Adaptive Mantel Test for AssociationTesting in Imaging Genetics Data
, 2018 Mantel's test (MT) for association is conducted by testing the linear relationship of similarity of all pairs of subjects between two observational domains.
Chen, Chuansheng +5 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Occupant behaviour in naturally ventilated and hybrid buildings [PDF]
, 2009 Adaptive thermal comfort criteria for building occupants are now becoming established. In this paper we illustrate their use in the prediction of occupant behaviour and make a comparison with a non-adaptive temperature threshold approach.
Clarke, J.A. +4 more
core
Protecting entanglement of twisted photons by adaptive optics
, 2018 We study the efficiency of adaptive optics (AO) correction for the free-space propagation of entangled photonic orbital-angular-momentum (OAM) qubit states, to reverse moderate atmospheric turbulence distortions.
Buchleitner, Andreas +4 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Varying Load Detection in A Gearbox System Based on Adaptive Threshold Estimation
MATEC Web of Conferences, 2016 This article presents an adaptive threshold computation for varying load detection in gearbox system. This method was applied on the vibration signal which is captured from gearbox housing.
Kouadri A., Ibrahim G.R., Albarbar A.
doaj +1 more source