Results 71 to 80 of about 149,547 (246)

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Adaptive Joint Control of Intersection Traffic Signals and Variable Lanes Using Multi‐Agent Learning

IET Intelligent Transport Systems
To effectively manage varying traffic flows at urban intersections during peak and off‐peak hours, especially under conditions of unbalanced directional demand, we propose a learning‐based coordination method for traffic signal control and variable ...
Menglin Wang, Haiyong Wang, Sheng Wei, Dan Zhang   +3 more
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Green Wave Traffic Optimization - A Survey [PDF]

, 2008
The objective of this survey is to cover the research in the area of adaptive traffic control with emphasis on the applied optimization methods. The problem of optimizing traffic signals can be viewed in various ways, depending on political, economic and
Jørgensen, Rene Munk, Larsen, Jesper, Warberg, Andreas   +2 more
core   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Design and Implementation of a Smart Traffic Signal Control System for Smart City Applications

Sensors, 2020
Infrastructure supporting vehicular network (V2X) capability is the key factor to the success of smart city because it enables many smart transportation services. In order to reduce the traffic congestion and improve the public transport efficiency, many
Wei-Hsun Lee, Chi-Yi Chiu
doaj   +1 more source

Vehicle Based Intersection Management with Intelligent Agents [PDF]

Signal-based intersection management will change when vehicles with intelligent capability are available in the future. Intelligent agents embedded in vehicle software will be responsible for vehicle control and route guidance.
David Levinson, Xi Zou
core  

Adaptive signal control using approximate dynamic programming [PDF]

, 2009
This paper presents a concise summary of a study on adaptive traffic signal controller for real time operation. The adaptive controller is designed to achieve three operational objectives: first, the controller adopts a dual control principle to achieve ...
Cai, C., Heydecker, B.
core  

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Dynamic Local Vehicular Flow Optimization Using Real-Time Traffic Conditions at Multiple Road Intersections

IEEE Access, 2019
Dynamic management of vehicular traffic congestion to maximize throughput in urban areas has been drawing increased attention in recent years. For that purpose, a number of adaptive control algorithms have been proposed for individual traffic lights ...
Sookyoung Lee, Mohamed Younis, Aiswarya Murali, Meejeong Lee   +3 more
doaj   +1 more source