Results 61 to 70 of about 34,023 (303)

Advances in Se Wide‐Bandgap Photovoltaics and TexSe1‐x SWIR Photodiodes

open access: yesAdvanced Science, EarlyView.
In this review, fundamental properties and current challenges in Se photovoltaics (PVs) for tandem and indoor PVs and TexSe1‐x alloys for short wave infrared photodiodes are discussed. A case is made for the practicality of elemental chalcogenide optoelectronics, and a pathway toward resolving the key challenges in these respective technologies is ...
Adam D. Alfieri, Deep Jariwala
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia   +8 more
wiley   +1 more source

ADAS 869 Comprehensive Examination

open access: yes, 1990
Course syllabus for ADAS 869 Comprehensive Examination Course description: This is the final course in the MHS-ADAS degree program. The comprehensive examination is intended to assess the student\u27s abilities to analyze, synthesize, and evaluate ...
Blevins, Greg   +2 more
core   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

open access: yesAdvanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha   +5 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

open access: yesAdvanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan   +7 more
wiley   +1 more source

From fault tolerance to fault detection: A DHR-based contrastive testing method and its validation on ADAS

open access: yesSecurity and Safety
Many modern complex systems, such as advanced driver assistance systems (ADAS), face the problems of dynamic and diverse test environments and unpredictable test results when performing black-box testing. This may lead to imprecise fault localization and
Qin Wutao   +3 more
doaj   +1 more source

The Nature of the ADAS Model Based on the ISLM Model [PDF]

open access: yes
The aggregate demand and supply model (ADAS) is interpreted as a synthesis of the Keynesian and neoclassical models. It uses the ISLM model, without explaining its nature, to derive aggregate demand (AD).
B Bhaskara Rao
core  

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

open access: yesAdvanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong   +15 more
wiley   +1 more source

Programming with Ada - the Ada environment

open access: yes, 2010
This paper examines two aspects of using Ada for the implementation of large program systems. First, those elements of the Ada language that are particularly targeted at programming in the large are discussed. Conclusions about appropriate design methodologies that match these language features are presented along with an explanation of some potential ...
openaire   +2 more sources

Collecting end-users needs regarding driver state-based automation in the ADAS&ME project [Elektronisk resurs]

open access: yes, 2018
The EU funded project ADAS&ME (Adaptive ADAS to support incapacitated drivers & Mitigate Effectively risks through tailor made HMI under automation) develops adapted Advanced Driver Assistance Systems.
Pereira Cocron, Marta,   +6 more
core  

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