Results 1 to 10 of about 2,548 (156)

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma. [PDF]

J Thorac Dis, 2023
The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients. Multiple biomarkers are reportedly involved in the proliferation or metastasis of adenocarcinoma. However, whether the ADCY9 gene influences the development of LUAD remains unknown.
Tang Y, Wang T, Zhang A, Zhu J, Zhou T, Zhou YL, Shi J.   +6 more
europepmc   +5 more sources

ADRB2 and ADCY9 Sequence Variations in Brazilian Asthmatic Patients. [PDF]

Curr Issues Mol Biol
Asthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process. The β2 agonists are bronchodilators prescribed for the relief of the disease.
Silva VDC, Teixeira RLF, do Livramento REENO, Lopes MQP, Leal-Calvo T, Filho JE, Luduvice MBV, Rodrigues LC, Bossois M, Schlinkert PF, Neves AS, Suffys PN, Lapa E Silva JR, Santos AR.   +13 more
europepmc   +6 more sources

Adenylate cyclase 9 expression level is associated with hormone receptor-positive breast cancer and predicts patient prognosis. [PDF]

Nagoya J Med Sci
Adenylate cyclase family members have recently received attention as novel therapeutic targets. However, the significance of adenylate cyclase 9 (ADCY9) in breast cancer has not been elucidated.
Sugino K, Shibata M, Adachi Y, Soeda I, Ichikawa T, Inaishi T, Kanaya E, Kanda M, Hayashi M, Masuda N.   +9 more
europepmc   +3 more sources

[Association of the ADCY9 gene and gene-environmental interaction with the susceptibility to childhood bronchial asthma]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi, 2022
Jia JJ, Wei B, Li LX, Ren MY, Zhang SN, Liu J, Zhang YX.   +6 more
europepmc   +3 more sources

Pharmacogenetics of inhaled long-acting beta2-agonists in asthma:a systematic review [PDF]

, 2018
Background: Long-acting beta2-agonists (LABA) are recommended in asthma therapy; however, not all asthma patients respond well to LABA. We performed a systematic review on genetic variants associated with LABA response in patients with asthma.
Ambrose, Basu, Bleecker, Bleecker, Bleecker, Bonini, Calhoun, Cariaso, Cazzola, Chung, Cooper, Currie, Drazen, Drysdale, Farzan, Giubergia, Harada, Jabbal, Jabbal, Kalra, Kersten, Kim, Kim, Konno, Lee, Lee, Lemanske, Leusink, Leusink, Li, Lima, Lipworth, Lipworth, Little, Maagdenberg, Mak, Mak, Manning, Moher, Nyenhuis, O'Byrne, Ortega, Ortega, Ortega, Palmer, Peters, Petrovic-Stanojevic, Rabe, Rebordosa, Reihsaus, Salpeter, Sears, Simons, Slankard, Soleimani, Spector, Tan, Taylor, Taylor, Tonk, Turner, Vijverberg, Wechsler, Wechsler, Wijesinghe, Wu, Yancey, Yawn, Zuurhout   +68 more
core   +14 more sources

The battle of the sexes starts in the oviduct: modulation of oviductal transcriptome by X and Y-bearing spermatozoa [PDF]

, 2014
BACKGROUND:Sex allocation of offspring in mammals is usually considered as a matter of chance, being dependent on whether an X- or a Y-chromosome-bearing spermatozoon reaches the oocyte first. Here we investigated the alternative possibility, namely that
Alminana, C., Caballero, I., Cuello, C., Fazeli, A., Gil, M., Heath, P., Holt, W., Maleki-Dizaji, S., Martinez, E., Parrilla, I., Roca, J., Vazquez, J., Vazquez, J.   +12 more
core   +3 more sources

microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements [PDF]

, 2015
MicroRNAs (miRNAs, micro ribonucleic acids) are pivotal post-transcriptional regulators of gene expression. These endogenous small non-coding RNAs play significant roles in tumorigenesis and tumor progression.
Brinkmann, B.F. (Benjamin), Brüggemann, K. (Kathrin), Ebnet, K. (Klaus), Engbers, A. (Annika), Götte, M. (Martin), Kemper, B. (Björn), Kiesel, L. (Ludwig), Riethmüller, C. (Christoph), Schwickert, A. (Alexander), Seggewiß, J. (Jochen), Stock, C. (Christian), Weghake, E. (Esther)   +11 more
core   +10 more sources

Association studies and direct DNA sequencing implicate some known genetic susceptibility loci in the etiology of nonsyndromic orofacial clefts in sub-Saharan African populations [PDF]

, 2016
Orofacial clefts (OFCs) are congenital dysmorphologies of the human face and oral cavity, with a global incidence of 1 per 700 live births. These anomalies exhibit multifactorial pattern of inheritance, with both genetic and environmental factors playing
A. Butali, A. Martinez, A.A. Adeyemo, A.A. Oti, B. Aregbesola, C.J. Buxó, E.A. Augustine-Akpan, F. Abate, F.K.N. Arthur, G. Plange-Rhule, G.O. Oseni, Gorlin RJ, J. Olutayo, J.C. Murray, L. Abdur-Rahman, L.J.J. Gowans, Liang J, M. Deribew, M. Eshete, M. Gesses, M. Li, M.L. Marazita, M.O. Ogunlewe, P. Agbenorku, P. Donkor, P. Gravem, P. Twumasi, P.A. Mossey, P.B. Olaitan, Pan X, R. Braimah, S. Obiri-Yeboah, S.A. Bello, T. Busch, T. Hailu, W. Deressa, W.L. Adeyemo, Weatherley-White RC   +37 more
core   +2 more sources

Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs [PDF]

, 2017
Background: One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3.
Hietakangas, Ville, Serenius, Timo, Sevon-Aimonen, Marja-Liisa, Uimari, Pekka, Verardo, Lucas L.   +4 more
core   +1 more source

Ulk4 regulates GABAergic signaling and anxiety-related behavior [PDF]

, 2018
Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine ...
A Cooper, A Hogart, A Lippa, A MacKenzie-Graham, A Marowsky, A Paydar, A Viggiano, AA Walf, AM Addington, B Burns, B Lang, B Lang, CB Nemeroff, CR Marshall, D Azzinnari, D Bosch, D Pinto, D Rujescu, DA Lewis, DM Kerr, DM Kerr, G Fenalti, G Kirov, GJ Qu, HU Wittchen, JJ Nadler, JJ Soghomonian, JN Crawley, JT Glessner, K Njunge, KD Micheva, KV Barnes, KV Sandhu, L Dominguez, LW Jin, M Liu, M Liu, M Seney, MJ Millan, MR Zarrindast, O Stork, P Muglia, PG Unschuld, RB Lydiard, RMJ Deacon, S Chung, S Heckers, S Muhie, SA Heldt, SF Kash, T Hashimoto, T Toyota, WC Skarnes, WF Schwindinger, WH Chou, Y Gonchar   +55 more
core   +3 more sources