ADRB2 and ADCY9 Sequence Variations in Brazilian Asthmatic Patients [PDF]
Current Issues in Molecular BiologyAsthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process.
Viviane da C. Silva +13 more
doaj +7 more sources
A sex-specific evolutionary interaction between ADCY9 and CETP [PDF]
eLife, 2021 Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction
Isabel Gamache +15 more
doaj +6 more sources
Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome [PDF]
Orphanet Journal of Rare Diseases, 2020 Background Rubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous studies have reported that large deletions contribute to more severe RTS phenotypes than those caused by CREBBP point mutations,
Yueheng Wu +19 more
doaj +11 more sources
ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma. [PDF]
J Thorac Dis, 2023 Background The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients.
Tang Y +6 more
europepmc +6 more sources
Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor [PDF]
Pharmaceutics, 2021 The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the ADYC9 gene in 163 patients in preterm labor were genotyped: rs879619 ...
Nari Lee +6 more
doaj +6 more sources
A Case–Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population [PDF]
Frontiers in Oncology, 2020 Background: Adenylyl cyclase type 9 (ADCY9) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that ADCY9 gene polymorphisms were associated with cancer development.
Xu Chao +8 more
doaj +5 more sources
Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in Triplophysa Loaches [PDF]
Ecology and EvolutionUnderstanding the adaptive evolution of brain function in extreme environments remains a central challenge in evolutionary biology. This study investigates the molecular mechanisms underlying cave adaptation by comparing brain transcriptomes of sympatric
Chunqing Li +4 more
doaj +4 more sources
Impact of ADCY9 Genotype on Response to Anacetrapib
Circulation, 2019 Supplemental Digital Content is available in the text.
J. Hopewell +9 more
semanticscholar +4 more sources
Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9 [PDF]
Functional & Integrative Genomics, 2021 Myocardial infarction (MI) is a significant cause of death and disability, and sevoflurane (sevo) can protect myocardium in clinic. We aim to assess the effects of miR-210-3p on MI rats undergoing sevo treatment with the involvement of adenylyl cyclase ...
Yahui Wu +3 more
semanticscholar +5 more sources
ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study [PDF]
JAMA Cardiology, 2018 A pharmacogenetic analysis of dalcetrapib, a cholesteryl ester transfer protein inhibitor, reported an association between a single-nucleotide polymorphism (SNP) in the ADCY9 gene (rs1967309) and reduction in major adverse cardiovascular events despite a neutral result for the overall trial.To determine whether the association between the SNP in the ...
S. Nissen +12 more
semanticscholar +5 more sources