Results 1 to 10 of about 1,125 (109)

A sex-specific evolutionary interaction between ADCY9 and CETP [PDF]

eLife, 2021
Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction
Isabel Gamache, Marc-André Legault, Jean-Christophe Grenier, Rocio Sanchez, Eric Rhéaume, Samira Asgari, Amina Barhdadi, Yassamin Feroz Zada, Holly Trochet, Yang Luo, Leonid Lecca, Megan Murray, Soumya Raychaudhuri, Jean-Claude Tardif, Marie-Pierre Dubé, Julie Hussin   +15 more
doaj   +9 more sources

ADRB2 and ADCY9 Sequence Variations in Brazilian Asthmatic Patients [PDF]

Current Issues in Molecular Biology
Asthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process.
Viviane da C. Silva, Raquel L. de F. Teixeira, Rebecca E. E. N. O. do Livramento, Márcia Q. P. Lopes, Thyago Leal-Calvo, José E. Filho, Márcia B. V. Luduvice, Lilian de C. Rodrigues, Marcello Bossois, Patricia F. Schlinkert, Anderson S. Neves, Philip N. Suffys, José Roberto Lapa e Silva, Adalberto R. Santos   +13 more
doaj   +6 more sources

Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor [PDF]

Pharmaceutics, 2021
The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the ADYC9 gene in 163 patients in preterm labor were genotyped: rs879619 ...
Nari Lee, Ha-Young Yoon, Jin-Young Park, Young-Ju Kim, Han-Sung Hwang, Jeong Yee, Hye-Sun Gwak   +6 more
doaj   +8 more sources

Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome [PDF]

Orphanet Journal of Rare Diseases, 2020
Background Rubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous studies have reported that large deletions contribute to more severe RTS phenotypes than those caused by CREBBP point mutations,
Yueheng Wu, Yu Xia, Ping Li, Hui-Qi Qu, Yichuan Liu, Yongchao Yang, Jijin Lin, Meng Zheng, Lifeng Tian, Zhuanbin Wu, Shufang Huang, Xianyu Qin, Xianwu Zhou, Shaoxian Chen, Yanying Liu, Yonghua Wang, Xiaofeng Li, Hanshi Zeng, Hakon Hakonarson, Jian Zhuang   +19 more
doaj   +11 more sources

A Case–Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population [PDF]

Frontiers in Oncology, 2020
Background: Adenylyl cyclase type 9 (ADCY9) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that ADCY9 gene polymorphisms were associated with cancer development.
Xu Chao, Xu Chao, Yong Jia, Xuesong Feng, Guoquan Wang, Xiaoping Wang, Hailong Shi, Fei Zhao, Chao Jiang   +8 more
doaj   +4 more sources

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma. [PDF]

J Thorac Dis, 2023
The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients. Multiple biomarkers are reportedly involved in the proliferation or metastasis of adenocarcinoma. However, whether the ADCY9 gene influences the development of LUAD remains unknown.
Tang Y, Wang T, Zhang A, Zhu J, Zhou T, Zhou YL, Shi J.   +6 more
europepmc   +5 more sources

The ADCY9 genetic variants are associated with glioma susceptibility and patient prognosis

Genomics, 2021
Genetic factor is a risk factor in glioma occurrence. This study was designed to detect the effect of ADCY9 polymorphisms on glioma risk and prognosis.We performed a case-control study of 1080 participants (584 cases and 496 controls) to assess the relationship of ADCY9 polymorphisms with the risk and prognosis of glioma among the Chinses Han ...
Luyi Zhang, Liang Wang, Gang Zhang, Hangyu Shi, Min Xi, Yang Zhangkai, Li Gao, Yuqian Li   +7 more
openaire   +4 more sources

Upregulated microRNA-210-3p improves sevoflurane-induced protective effect on ventricular remodeling in rats with myocardial infarction by inhibiting ADCY9 [PDF]

Functional & Integrative Genomics, 2021
Abstract ObjectiveMyocardial infarction (MI) is a significant cause of death and disability, and sevoflurane (sevo) can protect myocardium in clinic. We aim to assess the effects of miR-210-3p on MI rats undergoing sevo treatment with the involvement of adenylyl cyclase type 9 (ADCY9).MethodsRat MI models were constructed by ligation of the ...
Yahui Wu, Taofu Wang, Liang Qiao, Hongqi Lin   +3 more
  +6 more sources

Impact of ADCY9 Genotype on Response to Anacetrapib

Circulation, 2019
Background: Exploratory analyses of previous randomized trials generated a hypothesis that the clinical response to cholesteryl ester transfer protein (CETP) inhibitor therapy differs by ADCY9 genotype, prompting the ongoing dal-GenE trial in individuals with a particular genetic ...
Jemma C. Hopewell, Maysson Ibrahim, Michael Hill, Peter M. Shaw, Eugene Braunwald, Robert O. Blaustein, Louise Bowman, Martin J. Landray, Marc S. Sabatine, Rory Collins, L Jiang, CP Cannon, SD Wiviott, J Armitage, R Haynes, AP Maggioni, CE Angermann, G Ertl, C Wanner, T Pedersen, S Goto, T Teramoto, C Baigent, P Barter, Y Chen, Z Chen, A Gray, B Mihaylova, P Sleight, J Tobert, P DeLucca, Y Mitchel, G van Leijenhorst   +32 more
openaire   +4 more sources

ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease [PDF]

JAMA Cardiology, 2018
A pharmacogenetic analysis of dalcetrapib, a cholesteryl ester transfer protein inhibitor, reported an association between a single-nucleotide polymorphism (SNP) in the ADCY9 gene (rs1967309) and reduction in major adverse cardiovascular events despite a neutral result for the overall trial.To determine whether the association between the SNP in the ...
Pallav Bhatnagar, Kathy Wolski, Govinda Weerakkody, Steven E. Nissen, Lin Li, Wendra M. Foster, Jeffrey S. Riesmeyer, A. Michael Lincoff, Stephen J. Nicholls, Stephen J. Nicholls, Ellen McErlean, Giacomo Ruotolo, Sreekumar G. Pillai   +12 more
openaire   +4 more sources