Results 101 to 110 of about 1,135 (126)

Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice

Canadian Journal of Cardiology, 2023
Polymorphisms in the adenylate cyclase 9 (ADCY9) gene influence the benefits of the cholesteryl ester transfer protein (CETP) modulator dalcetrapib on cardiovascular events after acute coronary syndrome. We hypothesized that Adcy9 inactivation could improve cardiac function and remodelling following myocardial infarction (MI) in absence of CETP ...
Marine Ferron, Nolwenn Merlet, Téodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Marc‐Antoine Gillis, Yanfen Shi, Anna Nozza, Mariève Cossette, Marie‐Claude Guertin, Éric Rhéaume, Jean‐Claude Tardif   +11 more
semanticscholar   +4 more sources

The rs2601796 variant in ADCY9 gene is associated with severe asthma and less bronchodilator response

Gene, 2023
Asthma is a respiratory disease caused by the interaction of genetic and environmental factors. The adenylyl cyclase type 9 (ADCY9) enzyme produces the cyclic-adenosinemonophosphate (cAMP), important mediator involved in bronchodilation and immunomodulatory response.
Helena Mariana Pitangueira Teixeira, Álvaro A. Cruz, Talita S. Jesus, Maria Borges Rabêlo de Santana, Marinalva S. Jesus, Rafaela Tugores, Wedson S. Araujo, Rebeca C.C. Reis, Gabriela Pimentel Pinheiro, Camila Alexandrina Figueiredo, Ryan dos Santos Costa   +10 more
semanticscholar   +4 more sources

Assessment of ADCY9 polymorphisms and colorectal cancer risk in the Chinese Han population

The Journal of Gene Medicine, 2020
Recently, ADCY9 has been found to be highly expressed in colon cancer, and high ADCY9 expressionis a poor prognostic factor of colon cancer. However, no study has reported on the relationship between single nucleotide polymorphisms (SNPs) of ADCY9 and ...
Haiyue Li, Yuanwei Liu, Jianfeng Liu, Yao Sun, Jiamin Wu, Zichao Xiong, Qiu Zhang, Bin Li, Tianbo Jin   +8 more
semanticscholar   +5 more sources

Advancing Beyond Failed High-density Lipoprotein Clinical Trials to Pharmacogenetic Studies of ADCY9 and Cholesterol Ester Transfer Protein Inhibition

Journal of Cardiovascular Pharmacology, 2021
: Atherosclerosis has been effectively avoided with many therapies that lower low-density lipoprotein cholesterol. However, significant cardiovascular burden remains.
Donald M. Black, Michael Miller, Therèse Heinonen, Guili Zhang   +3 more
semanticscholar   +5 more sources

[Association of the ADCY9 gene and gene-environmental interaction with the susceptibility to childhood bronchial asthma].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2022
OBJECTIVES To study the association of the single nucleotide polymorphisms (SNPs) of the adenylyl cyclase IX (ADCY9) gene at rs1967309, rs2230739, rs2601814, rs2601825, rs2601796, and rs2283497 loci and gene-environment interaction with childhood ...
Jingjing Jia, Bing Wei, Lingxue Li, Mengyang Ren, Shi‐Nan Zhang, Jun Liu, Yuxuan Zhang   +6 more
semanticscholar   +4 more sources

Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders

American Journal of Medical Genetics, 2001
Chromosome 16p13 has been shown to display modest linkage signals for mood disorders in a number of studies. An interesting candidate gene in this region is the adenylate cyclase (AC) type 9 gene (ADCY9).
Tomoko Toyota, Eiji Hattori, Joanne Meerabux, Kazuo Yamada, Koji Saito, Haruo Shibuya, Masahiro Nankai, Takeo Yoshikawa   +7 more
semanticscholar   +5 more sources

ADCY9 Gene

Definitions, 2020

semanticscholar   +3 more sources

Abstract 624: Interactions Between Adenylate Cyclase Type 9 (ADCY9) and Cholesteryl Ester Transfer Protein (CETP) in Atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events, atherosclerosis imaging and body weight variation.
Yohann Rautureau, Vanessa Deschambault, Marie‐Eve Higgins, Daniel Rivas, Mélanie Mecteau, Pierre A. Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocío Sánchez, Audrey Nault, Pierre-Marc Williams, María Laura Suárez, Geneviève Brand, Line Lapointe, Natacha Duquette, Marc‐Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R. Brodeur, Sylvie Lévesque, Marie‐Claude Guertin, Marie‐Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean‐Claude Tardif   +28 more
semanticscholar   +4 more sources

Increase in Cardiovascular Events in Patients Treated with CETP Inhibitors is Associated with rs1967309 SNP in ADCY9 Gene

Atherosclerosis Supplements, 2018
Yue Fei, Man-Fung Tsoi, Bernard M.Y. Cheung   +2 more
semanticscholar   +4 more sources

Randomized Clinical Trial Needed to Confirm Whether Dalcetrapib Improves Outcomes for Specific ADCY9 Genotype

JAMA Cardiology, 2018
Marc A. Pfeffer, Marie‐Pierre Dubé, Jean‐Claude Tardif   +2 more
semanticscholar   +5 more sources