ADRB2 and ADCY9 Sequence Variations in Brazilian Asthmatic Patients [PDF]
Current Issues in Molecular BiologyAsthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process.
Viviane da C. Silva +13 more
doaj +7 more sources
Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor [PDF]
Pharmaceutics, 2021 The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the ADYC9 gene in 163 patients in preterm labor were genotyped: rs879619 ...
Nari Lee +6 more
doaj +9 more sources
Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome [PDF]
Orphanet Journal of Rare Diseases, 2020 Background Rubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous studies have reported that large deletions contribute to more severe RTS phenotypes than those caused by CREBBP point mutations,
Yueheng Wu +19 more
doaj +11 more sources
A Case–Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population [PDF]
Frontiers in Oncology, 2020 Background: Adenylyl cyclase type 9 (ADCY9) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that ADCY9 gene polymorphisms were associated with cancer development.
Xu Chao +8 more
doaj +5 more sources
A sex-specific evolutionary interaction between ADCY9 and CETP [PDF]
eLife, 2021 Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction
Isabel Gamache +15 more
doaj +8 more sources
ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma. [PDF]
J Thorac Dis, 2023 Background The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients.
Tang Y +6 more
europepmc +6 more sources
POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium channel TREK-1 in heart. [PDF]
EMBO Rep, 2022 The establishment of macromolecular complexes by scaffolding proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for cardiac functions.
Baldwin TA +11 more
europepmc +6 more sources
The epigenetic mechanisms of adaption to the hot and humid climate in Hu sheep (Ovis aries) [PDF]
Physiological ReportsHu sheep is characterized by its excellent fecundity and high adaptability to various ecological environments. To reveal the molecular basis involved in Hu sheep, we first examined the 10 index of neuroendocrine and metabolism in blood in Hu sheep during
Hangxing Ren +10 more
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Adenylate cyclase 9 expression level is associated with hormone receptor-positive breast cancer and predicts patient prognosis. [PDF]
Nagoya J Med SciAdenylate cyclase family members have recently received attention as novel therapeutic targets. However, the significance of adenylate cyclase 9 (ADCY9) in breast cancer has not been elucidated.
Sugino K +9 more
europepmc +4 more sources
Upregulated microRNA-210-3p Improves Sevoflurane-induced Protective Effect on Ventricular Remodeling in Rats With Myocardial Infarction by Inhibiting ADCY9 [PDF]
Functional & Integrative Genomics, 2021 Myocardial infarction (MI) is a significant cause of death and disability, and sevoflurane (sevo) can protect myocardium in clinic. We aim to assess the effects of miR-210-3p on MI rats undergoing sevo treatment with the involvement of adenylyl cyclase ...
Yahui Wu +3 more
semanticscholar +6 more sources