Results 11 to 20 of about 1,135 (126)

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma [PDF]

Journal of Thoracic Disease, 2023
Background The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients.
Yijie Tang, Tianyi Wang, Anping Zhang, Jiaqi Zhu, Tingting Zhou, Youlang Zhou, Jiahai Shi   +6 more
semanticscholar   +4 more sources

Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome [PDF]

Orphanet Journal of Rare Diseases, 2020
Rubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous studies have reported that large deletions contribute to more severe RTS phenotypes than those caused by CREBBP point mutations ...
Yueheng Wu, Yu Xia, Ping Li, Hui‐Qi Qu, Yichuan Liu, Yongchao Yang, Jijin Lin, Zheng Meng, Lifeng Tian, Zhuanbin Wu, Shufang Huang, Xianyu Qin, Xianwu Zhou, Shaoxian Chen, Yanying Liu, Yonghua Wang, Xiaofeng Li, Hanshi Zeng, Hákon Hákonarson, Jian Zhuang   +19 more
semanticscholar   +11 more sources

Upregulated microRNA-210-3p Improves Sevoflurane-induced Protective Effect on Ventricular Remodeling in Rats With Myocardial Infarction by Inhibiting ADCY9 [PDF]

Functional & Integrative Genomics, 2021
Myocardial infarction (MI) is a significant cause of death and disability, and sevoflurane (sevo) can protect myocardium in clinic. We aim to assess the effects of miR-210-3p on MI rats undergoing sevo treatment with the involvement of adenylyl cyclase ...
Yahui Wu, Taofu Wang, Liang Qiao, Hongqi Lin   +3 more
semanticscholar   +6 more sources

A Case–Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population [PDF]

Frontiers in Oncology, 2020
Background: Adenylyl cyclase type 9 (ADCY9) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that ADCY9 gene polymorphisms were associated with cancer development.
Xu Chao, Yong Jia, Xuesong Feng, Guoquan Wang, Xiaoping Wang, Hailong Shi, Fei Zhao, Chao Jiang   +7 more
semanticscholar   +5 more sources

Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor [PDF]

Pharmaceutics, 2021
The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the ADYC9 gene in 163 patients in preterm labor were genotyped: rs879619 ...
Nari Lee, Ha-Young Yoon, Jin Young Park, Young Ju Kim, Han Sung Hwang, Jeong Yee, Hye Sun Gwak   +6 more
semanticscholar   +7 more sources

The ADCY9 genetic variants are associated with glioma susceptibility and patient prognosis

Genomics, 2020
Genetic factor is a risk factor in glioma occurrence. This study was designed to detect the effect of ADCY9 polymorphisms on glioma risk and prognosis.We performed a case-control study of 1080 participants (584 cases and 496 controls) to assess the relationship of ADCY9 polymorphisms with the risk and prognosis of glioma among the Chinses Han ...
Gang Zhang, Min Xi, Yuqian Li, Liang Wang, Li Gao, Luyi Zhang, Zhangkai Yang, Hangyu Shi   +7 more
semanticscholar   +5 more sources

ADRB2 and ADCY9 Sequence Variations in Brazilian Asthmatic Patients [PDF]

Current Issues in Molecular Biology
Asthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process.
V.D. Silva, Raquel Lima de Figueiredo Teixeira, Rebecca E. E. N. O. do Livramento, Márcia Quinhones Pires Lopes, Thyago Leal-Calvo, JOSÉ EMILIANO CRUZ FILHO, Márcia B. V. Luduvice, Lilian Rodrigues, Marcello Bossois, Patricia F. Schlinkert, Anderson S. Neves, Philip Noël Suffys, José Roberto Lapa e Silva, Adalberto Rezende Santos   +13 more
semanticscholar   +5 more sources

Impact of ADCY9 Genotype on Response to Anacetrapib

Circulation, 2019
Supplemental Digital Content is available in the text.
Jemma C. Hopewell, M Ibrahim, Michael Hill, Peter Shaw, Eugene Braunwald, Robert O. Blaustein, Louise Bowman, Martin Landray, Marc S. Sabatine, Rory Collins, Lixin Jiang, CP Cannon, SD Wiviott, Jane Armitage, Richard Haynes, Aldo P. Maggioni, C Angermann, Georg Ertl, Christoph Wanner, Terje Pedersen, Shinya Goto, Tsukasa Teramoto, Colin Baigent, Philip J. Barter, Y Chen, Z Chen, Alastair Gray, Borislava Mihaylova, Peter Sleight, Jonathan A. Tobert, Paul DeLucca, Yale Mitchel, G. van Leijenhorst   +32 more
semanticscholar   +5 more sources

ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease [PDF]

JAMA Cardiology, 2018
A pharmacogenetic analysis of dalcetrapib, a cholesteryl ester transfer protein inhibitor, reported an association between a single-nucleotide polymorphism (SNP) in the ADCY9 gene (rs1967309) and reduction in major adverse cardiovascular events despite a neutral result for the overall trial.To determine whether the association between the SNP in the ...
Steven E. Nissen, Sreekumar Pillai, Stephen J. Nicholls, Kathy Wolski, Jeffrey S. Riesmeyer, Govinda J. Weerakkody, Wendra M. Foster, Ellen McErlean, Lin Li, Pallav Bhatnagar, Giacomo Ruotolo, A. Michael Lincoff   +11 more
semanticscholar   +5 more sources

ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein) [PDF]

Circulation, 2018
Background: Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the CETP (cholesteryl ester transfer protein) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging.
Yohann Rautureau, Vanessa Deschambault, Marie‐Eve Higgins, Daniel Rivas, Mélanie Mecteau, Pierre A. Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocío Sánchez, Véronique Lavoie, Geneviève Brand, Audrey Nault, Pierre-Marc Williams, María Laura Suárez, Nolwenn Merlet, Line Lapointe, Natacha Duquette, Marc‐Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R. Brodeur, Sylvie Lévesque, Marie‐Claude Guertin, Marie‐Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean‐Claude Tardif   +30 more
semanticscholar   +4 more sources