Results 11 to 20 of about 2,548 (156)
Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome [PDF]
Orphanet Journal of Rare Diseases, 2020 AbstractBackgroundRubinstein–Taybi syndrome (RTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder. Previous studies have reported that large deletions contribute to more severe RTS phenotypes than those caused by CREBBP point mutations, suggesting a concurrent pathogenetic role of flanking genes, typical of contiguous gene ...
Yueheng Wu +19 more
+11 more sources
A sex-specific evolutionary interaction between ADCY9 and CETP [PDF]
eLife, 2021 Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction is still unknown.
Isabel Gamache +15 more
openalex +4 more sources
Author response: A sex-specific evolutionary interaction between ADCY9 and CETP
, 2021 Isabel Gamache +15 more
openalex +2 more sources
Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor [PDF]
Pharmaceutics, 2021 The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the ADYC9 gene in 163 patients in preterm labor were genotyped: rs879619, rs2601796, rs2531988, rs2531995, and rs2230739.
Nari Lee +6 more
openalex +5 more sources
Impact of ADCY9 Genotype on Response to Anacetrapib
Circulation, 2019 Background: Exploratory analyses of previous randomized trials generated a hypothesis that the clinical response to cholesteryl ester transfer protein (CETP) inhibitor therapy differs by ADCY9 genotype, prompting the ongoing dal-GenE trial in individuals with a particular genetic ...
Jemma C. Hopewell +32 more
openalex +3 more sources
ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease [PDF]
JAMA Cardiology, 2018 A pharmacogenetic analysis of dalcetrapib, a cholesteryl ester transfer protein inhibitor, reported an association between a single-nucleotide polymorphism (SNP) in the ADCY9 gene (rs1967309) and reduction in major adverse cardiovascular events despite a neutral result for the overall trial.To determine whether the association between the SNP in the ...
Steven E. Nissen +11 more
openalex +4 more sources
Brain Transcriptomics Reveals Molecular Mechanisms of Cave Adaptation in <i>Triplophysa</i> Loaches. [PDF]
Ecol EvolThis study compares brain transcriptomes of cave (Triplophysa shilinensis) and surface‐dwelling (T. xiangshuingensis) loaches to uncover molecular adaptations to subterranean life. We identified widespread gene down‐regulation in the cave ecotype, with enriched pathways in energy metabolism, circadian rhythms, sensory perception, and body coloration ...
Li C, Wu L, Hu F, Chen S, Xiao H.
europepmc +2 more sources
Decision letter: A sex-specific evolutionary interaction between ADCY9 and CETP
, 2021 Eduardo Tarazona-Santos
openalex +2 more sources