Results 21 to 30 of about 2,548 (156)

A Case–Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population [PDF]

Frontiers in Oncology, 2020
Background: Adenylyl cyclase type 9 (ADCY9) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that ADCY9 gene polymorphisms were associated with cancer development. The aim of this study was to investigate whether ADCY9 gene polymorphisms could contribute to the susceptibility of hepatocellular carcinoma ...
Chao Xu, Yong Jia, Xuesong Feng, Guoquan Wang, Xiaoping Wang, Hailong Shi, Fei Zhao, Chao Jiang   +7 more
openalex   +4 more sources

Genetics of Common Obesity in Children and Adolescents. [PDF]

Ann N Y Acad Sci
Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
León-Reyes G, Alavez FJL, Tejero ME.
europepmc   +2 more sources

The epigenetic mechanisms of adaption to the hot and humid climate in Hu sheep (Ovis aries). [PDF]

Physiol Rep
Abstract Hu sheep is characterized by its excellent fecundity and high adaptability to various ecological environments. To reveal the molecular basis involved in Hu sheep, we first examined the 10 index of neuroendocrine and metabolism in blood in Hu sheep during non‐stress period (April–May) and stress period (July–August) using ELISA, including CRH ...
Ren H, Jiang J, Li J, Sun X, Chen C, Liu L, Lv S, Qu M, Fan Y, Zhou P, Wang G.   +10 more
europepmc   +2 more sources

Higher expression of mir-31-5p is associated with reduced risk of head and neck keloid recurrence following surgical resection. [PDF]

Laryngoscope Investig Otolaryngol
MicroRNA‐31‐5p expression in head and neck keloid formalin fixed paraffin embedded tissue is associated with recurrence, 1 year following treatment with surgery. MicroRNA‐3‐5p potential as a prognostic biomarker should be further investigated. Abstract Objective In this study, we aimed to evaluate mir‐31‐5p as a prognostic biomarker of keloid disease ...
Levin AM, Okifo O, Buhl K, Ouchi T, Parker B, Tan J, Datta I, Dai X, Chen Y, Palanisamy N, Veenstra J, Carskadon S, Li J, Ozog D, Keller CE, Chitale D, Bobbitt KR, Crawford HC, Steele N, Mi QS, Jones LR.   +20 more
europepmc   +2 more sources

ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein) [PDF]

Circulation, 2018
Background: Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the CETP (cholesteryl ester transfer protein) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between
Yohann Rautureau, Vanessa Deschambault, Marie‐Eve Higgins, Daniel Rivas, Mélanie Mecteau, Pierre A. Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocío Sánchez, Véronique Lavoie, Geneviève Brand, Audrey Nault, Pierre-Marc Williams, María Laura Suárez, Nolwenn Merlet, Line Lapointe, Natacha Duquette, Marc‐Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R. Brodeur, Sylvie Lévesque, Marie‐Claude Guertin, Marie‐Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean‐Claude Tardif   +30 more
openalex   +3 more sources

An Ile to Met Polymorphism in ADCY9 Promotes Airway Obstruction and Remodeling in Asthma

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Limei Liang, Pengcheng Cai, Yu Fan, Xin‐Liang He, Linjie Song, Yuzhi Lu, Qian Niu, Yaya Zhou, Lijuan Jiang, Ye-Han Jiang, Zi-Heng Jia, Liqin Zhao, Meng Wang, Peipei Cheng, Shuai-Jun Chen, Xiao Feng, Qian Li, Xiao-Lin Cui, Liang Xiong, Xiang Fei, Xiaorong Wang, Hong Ye, Wan‐Li Ma   +22 more
  +4 more sources

Exploring Genetic Markers for Cold-Heat Patterns: Integrating Traditional Medicine With Modern Genomic Research. [PDF]

Genet Res (Camb)
Background Temperature sensitivity has gained considerable attention in the era of precision medicine. This trait has long been used to identify cold–heat patterns (C‐HPs), a diagnostic framework in Traditional Korean Medicine that categorizes individuals based on their thermal responses.
Jeong S, Lee S.
europepmc   +2 more sources

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation [PDF]

, 2016
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo .
Andersson, TB, Bell, CC, Ellis, E, Goldring, CE, Hendriks, DFG, Ingelman-Sundberg, M, Johansson, I, Lauschke, VM, Mkrtchian, S, Moro, SML, Nordling, A, Park, BK, Rezayee, F, Sison-Young, R, Vorrink, SU   +14 more
core   +1 more source

Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages [PDF]

, 2015
Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown.
Chen, M., España, J., Ferrer, Isidro (Ferrer Abizanda), Martín, Elsa, Parra-Damas, A., Rodríguez-Álvarez, José, Saura Antolín, Carlos A. (Carlos Alberto), Valero, J.   +7 more
core   +6 more sources

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition [PDF]

, 2014
BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents remains a formidable challenge2, 4.
Donahue, Melanie K., Flaherty, Keith T., Frederick, Dennie T., Garraway, Levi A., Johannessen, Cory M., Johnson, Laura A., Narayan, Rajiv, Piccioni, Federica, Root, David E., Townes, Aisha, Wargo, Jennifer A.   +10 more
core   +1 more source