Defective BVES-mediated feedback control of cAMP in muscular dystrophy. [PDF]
Nat Commun, 2023 cAMP is an important second messenger involved in many aspects of biological processes. Here, Li et al. shows that blood vessel epicardial substance (BVES) is a negative regulator of cAMP signaling required for maintaining muscle mass and function ...
Li H +5 more
europepmc +2 more sources
Selection signature analysis using whole genome resequencing data reveals candidate genes for white plumage color in Korean native ducks [PDF]
Animal BioscienceObjective Domestication alters the phenotypes of wild animals to meet human demands and leaves characteristic patterns in their genomes. Various selection signature analysis methods have been developed to identify these characteristic patterns left in ...
Jaewon Kim +8 more
doaj +2 more sources
Serum miR-329-3p as a potential biomarker for poor ovarian response in an in vitro fertilization. [PDF]
Clin Exp Reprod MedObjective Several miRNAs have been identified as differentially expressed in patients with poor ovarian response (POR) compared to those with normal responses. This study aims to assess the potential of serum miR-329-3p as a biomarker for diagnosing POR.
Kim JH +8 more
europepmc +2 more sources
Study of FOXL2 Regulation on Ovarian Function in Chlamys farreri Through Comparative ChIP-Seq and Transcriptome Analysis Using RNA Interference [PDF]
BiologyFOXL2 (forkhead box protein L2) is a transcription factor, its function and regulatory mechanism have been mainly studied in mammals; related research on marine invertebrates is still insufficient.
Xiaoling Liu +5 more
doaj +2 more sources
Exploring Genetic Markers for Cold-Heat Patterns: Integrating Traditional Medicine With Modern Genomic Research. [PDF]
Genet Res (Camb)Background Temperature sensitivity has gained considerable attention in the era of precision medicine. This trait has long been used to identify cold–heat patterns (C‐HPs), a diagnostic framework in Traditional Korean Medicine that categorizes individuals based on their thermal responses.
Jeong S, Lee S.
europepmc +2 more sources
Gene-Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors. [PDF]
Int J Mol Sci, 2023 Asthma is a complex heterogeneous disease caused by gene–environment interactions. Although numerous genome-wide association studies have been conducted, these interactions have not been systemically investigated.
Cha J, Choi S.
europepmc +2 more sources
Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial. [PDF]
Eur Heart J, 2022 Aims In a retrospective analysis of dal-Outcomes, the effect of dalcetrapib on cardiovascular events was influenced by an adenylate cyclase type 9 (ADCY9) gene polymorphism.
Tardif JC +18 more
europepmc +2 more sources
Choosing sweeteners wisely—nutrigenetic study on childhood obesity [PDF]
Nutrition & MetabolismBackground This study investigated the association of specific sweet-taste and obesity-related genes with sweetener consumption patterns among children and the interaction between these genetic factors and sweetener intake on the risk of childhood ...
Daniel Wang Qiu +8 more
doaj +2 more sources
Author response: A sex-specific evolutionary interaction between ADCY9 and CETP
, 2021 Isabel Gamache +15 more
openalex +2 more sources
Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes. [PDF]
Br J CancerInvestigations of the non-coding region are essential for uncovering the full spectrum of genetic drivers in melanoma. Here, we map distal, non-coding, promoter-interacting regulatory elements using Hi-C data from melanoma cells and integrating these ...
Pudjihartono M +3 more
europepmc +2 more sources