Results 31 to 40 of about 1,135 (126)
Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas. [PDF]
Journal of Clinical Investigation, 2016 Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein α subunit (GNAS) are found in approximately 70% of ATAs.
D. Calebiro +18 more
semanticscholar +3 more sources
Author response: A sex-specific evolutionary interaction between ADCY9 and CETP
, 2021 Isabel Gamache +15 more
openalex +2 more sources
Pharmacogenetics of inhaled long-acting beta2-agonists in asthma:a systematic review [PDF]
, 2018 Background: Long-acting beta2-agonists (LABA) are recommended in asthma therapy; however, not all asthma patients respond well to LABA. We performed a systematic review on genetic variants associated with LABA response in patients with asthma.
Ambrose +68 more
core +14 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes
British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +28 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 7, Page 569-582, July 2023., 2023 Highlights Interactions of environmental factors and epigenome in early life, via environmentally modified epigenetic markers, affect the transcript profiles of pancreatic islets and peripheral insulin target organs, increasing the susceptibility of developing diabetes.
Hong Zhu +3 more
wiley +1 more source
Aging Cell, Volume 22, Issue 5, May 2023., 2023 Bifunctional immunotherapeutic HCW9218 functions as a novel SNC‐reducing and senomorphic agent in mice. Subcutaneous administration of HCW9218 activates NK, innate lymphoid group‐1, and CD8+ T cells, and neutralizes TGF‐ß to reduce senescent cells (SNC‐reducing) and SASP (senomorphic) leading to lower chronic inflammation and restored tissue ...
Niraj Shrestha +37 more
wiley +1 more source
Clinical and Translational Allergy, Volume 13, Issue 3, March 2023., 2023 Abstract Asthma is an important health concern in Latin America (LA) where it is associated with variable prevalence and disease burden between countries. High prevalence and morbidity have been observed in some regions, particularly marginalized urban populations.
Philip J. Cooper +17 more
wiley +1 more source
The FASEB Journal, Volume 37, Issue 2, February 2023., 2023 Abstract The Chinese forest musk deer (FMD; Moschus berezovskii) is an endangered artiodactyl mammal. Musk secreted by the musk gland of male has extremely high economic and medicinal value. However, the molecular and cellular characteristics of the musk gland have not been studied. Here, we investigated the diversity and transcriptional composition of
Chenmiao Liu +5 more
wiley +1 more source
Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs [PDF]
, 2017 Background: One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3.
Hietakangas, Ville +4 more
core +1 more source
Membrane protein biogenesis at the ER: the highways and byways
The FEBS Journal, Volume 289, Issue 22, Page 6835-6862, November 2022., 2022 In eukaryotes, one third of cellular proteins are co‐translationally inserted into or translocated across the membrane of the endoplasmic reticulum during their biogenesis. Here, we distil recent advances in our understanding of this process; highlighting the Sec61 translocon as a dynamic hub that co‐ordinates the roles of key partners to provide a ...
Sarah O'Keefe +2 more
wiley +1 more source