Results 31 to 40 of about 2,141 (173)

Higher expression of mir-31-5p is associated with reduced risk of head and neck keloid recurrence following surgical resection. [PDF]

Laryngoscope Investig Otolaryngol
MicroRNA‐31‐5p expression in head and neck keloid formalin fixed paraffin embedded tissue is associated with recurrence, 1 year following treatment with surgery. MicroRNA‐3‐5p potential as a prognostic biomarker should be further investigated. Abstract Objective In this study, we aimed to evaluate mir‐31‐5p as a prognostic biomarker of keloid disease ...
Levin AM, Okifo O, Buhl K, Ouchi T, Parker B, Tan J, Datta I, Dai X, Chen Y, Palanisamy N, Veenstra J, Carskadon S, Li J, Ozog D, Keller CE, Chitale D, Bobbitt KR, Crawford HC, Steele N, Mi QS, Jones LR.   +20 more
europepmc   +2 more sources

Transcriptomic Analysis Provides New Insights into Oocyte Growth and Maturation in Greater Amberjack (Seriola dumerili) [PDF]

Animals
The greater amberjack (Seriola dumerili) is an emerging marine fish that is increasingly favored in aquaculture. Currently, there are few studies on the development and regulation of greater amberjack ovaries.
Jiahui Yang, Xiaoying Ru, Yang Huang, Jinhui Wu, Tonglin Yang, Peipei Chen, Jin Li, Kunfeng Zhu, Chunhua Zhu   +8 more
doaj   +2 more sources

Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying Chelidonium majus L. in the treatment of allergic asthma [PDF]

Chinese Medicine
Background Chelidonium majus is a well-known traditional Chinese medicine, and has been reported of the effect in relieving cough and asthma. However, the mechanism of action is still unknown.
Renguang Wang, Xintong Sui, Xin Dong, Liming Hu, Zhimeng Li, Hang Yu, Cuicui Li, Guoxin Ji, Shumin Wang   +8 more
doaj   +2 more sources

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis [PDF]

Frontiers in Immunology, 2019
Objectives: Regulatory T cells (Tregs) are frequently functionally impaired in patients with granulomatosis with polyangiitis (GPA). However, the mechanism underlying their impaired function is unknown.
Gerjan J. Dekkema, Theo Bijma, Theo Bijma, Pytrick G. Jellema, Anke Van Den Berg, Bart-Jan Kroesen, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad, Wayel H. Abdulahad, Jan-Stephan Sanders   +10 more
doaj   +3 more sources

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis [PDF]

Haematologica, 2020
Chromosomal translocations involving the KMT2A gene are among the most common genetic alterations found in pediatric acute myeloid leukemias although the molecular mechanisms that initiate the disease remain incompletely defined.
Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques, Safia Safa-Tahar-Henni, Eva Bresson, Anne Bergeron, Josée Hebert, Soheil Meshinchi, Sonia Cellot, Frédéric Barabé, Brian T Wilhelm   +11 more
doaj   +3 more sources

A sex-specific evolutionary interaction betweenADCY9andCETP [PDF]

bioRxiv, 2021
Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction
Isabel Gamache, Marc‐André Legault, Jean‐Christophe Grenier, Rocío Sánchez, Éric Rhéaume, Samira Asgari, Amina Barhdadi, Yassamin Feroz Zada, Holly Trochet, Yang Luo, Leonid Lecca, Megan Murray, Soumya Raychaudhuri, Jean‐Claude Tardif, Marie‐Pierre Dubé, Julie Hussin   +15 more
openalex   +2 more sources

A novel feature selection algorithm for identifying hub genes in lung cancer [PDF]

Scientific Reports, 2023
Lung cancer, a life-threatening disease primarily affecting lung tissue, remains a significant contributor to mortality in both developed and developing nations.
Tehnan I. A. Mohamed, Absalom E. Ezugwu, Jean Vincent Fonou-Dombeu, Mohanad Mohammed, Japie Greeff, Murtada K. Elbashir   +5 more
doaj   +2 more sources

Genome-wide detection of selection signatures in Jianli pigs reveals novel cis-regulatory haplotype in EDNRB associated with two-end black coat color [PDF]

BMC Genomics
Background Jianli pig, a renowned indigenous breed in China, has the characteristics of a two-end black (TEB) coat color, excellent meat quality, strong adaptability and increased prolificacy. However, there is limited information available regarding the
Zhong Xu, Junjing Wu, Yu Zhang, Mu Qiao, Jiawei Zhou, Yue Feng, Zipeng Li, Hua Sun, Ruiyi Lin, Zhongxu Song, Haizhong Zhao, Lianghua Li, Nanqi Chen, Yujie Li, Favour Oluwapelumi Oyelami, Xianwen Peng, Shuqi Mei   +16 more
doaj   +2 more sources

Elevated PDE4C level serves as a candidate diagnostic biomarker and correlates with poor survival in thyroid carcinoma [PDF]

Scientific Reports
Thyroid carcinoma (THCA) is the most common endocrine cancer. Phosphodiesterase (PDE) 4 enzyme family, as specific regulator of cyclic adenosine monophosphate, may play a important role in THCA.
Ying Wang, Yongsheng Zhang, Yanyan Li, Jing Huang   +3 more
doaj   +2 more sources

Genetic Modifiers of Stroke in Patients with Sickle Cell Disease—A Scoping Review [PDF]

Int J Mol Sci
This work was partially supported by H&TRC, FCT/MCTES grant number (UIDB/05608/2020 and UIDP/05608/2020) and the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Talent Development Award.Sickle cell disease (SCD) clinically manifests ...
Oni M, Brito M, Rotman C, Archer N.
europepmc   +3 more sources