Results 41 to 50 of about 2,548 (156)
The human intelligence evolved from proximal cis‐regulatory saltations
Quantitative Biology, Volume 13, Issue 2, June 2025.Abstract The divergence rate between the alignable genomes of humans and chimpanzees is as little as 1.23%. Their phenotypical difference was hypothesized to be accounted for by gene regulation. We construct the cis‐regulatory element frequency (CREF) matrix to represent the proximal regulatory sequences for each species.
Xiaojie Li, Jianhui Shi, Lei M. Li
wiley +1 more source
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice
British Journal of Pharmacology, Volume 182, Issue 5, Page 1143-1163, March 2025.Abstract Background and Purpose Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications and lacks a definitive cure. Both pneumoconiosis and idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics.
Lu Bai +11 more
wiley +1 more source
Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption [PDF]
, 2013 The objectives of this study were to determine innate differences in gene expression in 2 regions of the extended amygdala between 5 different pairs of lines of male rats selectively bred for high or low ethanol consumption: a) alcohol-preferring (P) vs.
Bell, Richard L. +9 more
core +1 more source
Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature [PDF]
, 2016 Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and ...
Aricò, Eleonora +11 more
core +1 more source
Genetic Landscape of Obesity in Children: Research Advances and Prospects
Journal of Obesity, Volume 2025, Issue 1, 2025.Obesity is a chronic metabolic disease characterized by excessive accumulation or uneven distribution of fat in the body, which poses a serious threat to health. Obesity significantly increases the risk of developing сonditions such as type 2 diabetes, coronary heart disease, hypertension, obstructive sleep apnea, and some types of cancer.
Rita Khusainova +11 more
wiley +1 more source
Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. [PDF]
, 2016 We present here a novel genetic algorithm-based random forest (GARF) modeling technique that enables a reduction in the complexity of large gene disease signatures to highly accurate, greatly simplified gene panels.
Coppola, Giovanni +7 more
core +2 more sources
Insights into RNA‐mediated pathology in new mouse models of Huntington's disease
The FASEB Journal, Volume 38, Issue 23, 15 December 2024.The behavioral and molecular characterization was performed for Huntington's disease mouse models expressing a fragment of the human HTT gene, with mutation of ~100 CAG repeats, in the nontranslated version (HD/100CAG) and the translated version (HD/100Q). Abstract Huntington's disease (HD) is a neurodegenerative polyglutamine (polyQ) disease resulting
Magdalena Wozna‐Wysocka +12 more
wiley +1 more source
Is personalized medicine achievable in obstetrics? [PDF]
, 2014 Personalized medicine seeks to identify the right dose of the right drug for the right patient at the right time. Typically, individualization of therapy is based on the pharmacogenomic makeup of the individual and environmental factors that alter drug ...
Flockhart, David A. +2 more
core +1 more source
Insect Molecular Biology, Volume 33, Issue 6, Page 756-776, December 2024.Random drift rather than selection is the primary evolutionary force driving genomic and phenotypic variation in BSF populations during early phases of domestication. Functional trade‐offs between production and fitness traits were observed in BSF populations.
Kelvin L. Hull +5 more
wiley +1 more source