The battle of the sexes starts in the oviduct: modulation of oviductal transcriptome by X and Y-bearing spermatozoa [PDF]
, 2014 BACKGROUND:Sex allocation of offspring in mammals is usually considered as a matter of chance, being dependent on whether an X- or a Y-chromosome-bearing spermatozoon reaches the oocyte first. Here we investigated the alternative possibility, namely that
Alminana, C. +12 more
core +3 more sources
Rapid evolution fuels transcriptional plasticity to ocean acidification
Global Change Biology, Volume 28, Issue 9, Page 3007-3022, May 2022., 2022 Elevated pCO2 induced common molecular responses related to circadian rhythm and immune system but different magnitudes of response across six species. Acanthochromis polyacanthus exhibited many more differentially expressed genes with a more rapid evolutionary rate fuelling the increased transcriptional plasticity Abstract Ocean acidification (OA) is ...
Jingliang Kang +6 more
wiley +1 more source
Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages [PDF]
, 2014 Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown.
Chen, Meng +7 more
core +5 more sources
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study [PDF]
, 2018 Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum ...
Alexander, W Macharia +28 more
core +1 more source
Ulk4 regulates GABAergic signaling and anxiety-related behavior [PDF]
, 2018 Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine ...
A Cooper +55 more
core +3 more sources
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation [PDF]
, 2016 Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo .
Andersson, TB +14 more
core +1 more source
Gene–Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors
International Journal of Molecular Sciences, 2023 Asthma is a complex heterogeneous disease caused by gene–environment interactions. Although numerous genome-wide association studies have been conducted, these interactions have not been systemically investigated.
Junho Cha, Sungkyoung Choi
semanticscholar +1 more source
Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial
European Heart Journal, 2022 Aims In a retrospective analysis of dal-Outcomes, the effect of dalcetrapib on cardiovascular events was influenced by an adenylate cyclase type 9 (ADCY9) gene polymorphism.
J. Tardif +17 more
semanticscholar +1 more source
Defective BVES-mediated feedback control of cAMP in muscular dystrophy
Nature Communications, 2023 cAMP is an important second messenger involved in many aspects of biological processes. Here, Li et al. shows that blood vessel epicardial substance (BVES) is a negative regulator of cAMP signaling required for maintaining muscle mass and function ...
Haiwen Li +5 more
semanticscholar +1 more source
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition [PDF]
, 2014 BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents remains a formidable challenge2, 4.
Donahue, Melanie K. +10 more
core +1 more source