Results 41 to 50 of about 2,762 (187)

Pharmacogenetics of inhaled long-acting beta2-agonists in asthma:a systematic review [PDF]

open access: yes, 2018
Background: Long-acting beta2-agonists (LABA) are recommended in asthma therapy; however, not all asthma patients respond well to LABA. We performed a systematic review on genetic variants associated with LABA response in patients with asthma.
Ambrose   +68 more
core   +14 more sources

Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

open access: yesFrontiers in Genetics, 2021
BackgroundLung cancer is the tumor with the highest morbidity and mortality, and has become a global public health problem. The incidence of lung cancer in men has declined in some countries and regions, while the incidence of lung cancer in women has ...
Sinong Jia   +6 more
doaj   +1 more source

Comparative Transcriptomics of Gonads Reveals the Molecular Mechanisms Underlying Gonadal Development in Giant Freshwater Prawns (Macrobrachium rosenbergii)

open access: yesJournal of Marine Science and Engineering, 2022
The giant freshwater prawn, Macrobrachium rosenbergii, is a prawn that has economic significance throughout the world. It exhibits sex-related growth dimorphism, whereby the males grow significantly more rapidly than the females.
Guang Yang   +7 more
doaj   +1 more source

Identification and Characterization of Biomarkers and Their Role in Opioid Addiction by Integrated Bioinformatics Analysis

open access: yesFrontiers in Neuroscience, 2020
Although numerous studies have confirmed that the mechanisms of opiate addiction include genetic and epigenetic aspects, the results of such studies are inconsistent.
Xiuning Zhang   +8 more
doaj   +1 more source

Transcriptomics and sequencing analysis of gene expression profiling for major depressive disorder

open access: yesIndian Journal of Psychiatry, 2021
Background: Major depressive disorder (MDD) is a common psychiatric disorder characterized by constant sadness and a lack of interest in work and social interactions.
Pragya Verma, Madhvi Shakya
doaj   +1 more source

The battle of the sexes starts in the oviduct: modulation of oviductal transcriptome by X and Y-bearing spermatozoa [PDF]

open access: yes, 2014
BACKGROUND:Sex allocation of offspring in mammals is usually considered as a matter of chance, being dependent on whether an X- or a Y-chromosome-bearing spermatozoon reaches the oocyte first. Here we investigated the alternative possibility, namely that
Alminana, C.   +12 more
core   +3 more sources

Association studies and direct DNA sequencing implicate some known genetic susceptibility loci in the etiology of nonsyndromic orofacial clefts in sub-Saharan African populations [PDF]

open access: yes, 2016
Orofacial clefts (OFCs) are congenital dysmorphologies of the human face and oral cavity, with a global incidence of 1 per 700 live births. These anomalies exhibit multifactorial pattern of inheritance, with both genetic and environmental factors playing
A. Butali   +37 more
core   +2 more sources

Melatonin Alleviates the Suppressive Effect of Hypoxanthine on Oocyte Nuclear Maturation and Restores Meiosis via the Melatonin Receptor 1 (MT1)-Mediated Pathway

open access: yesFrontiers in Cell and Developmental Biology, 2021
It is well known that hypoxanthine (HX) inhibits nuclear maturation of oocytes by elevating the intracellular cAMP level, while melatonin (MT) is a molecule that reduces cAMP production, which may physiologically antagonize this inhibition and restore ...
Jing Wang   +11 more
doaj   +1 more source

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis

open access: yesFrontiers in Immunology, 2019
Objectives: Regulatory T cells (Tregs) are frequently functionally impaired in patients with granulomatosis with polyangiitis (GPA). However, the mechanism underlying their impaired function is unknown.
Gerjan J. Dekkema   +10 more
doaj   +1 more source

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis

open access: yesHaematologica, 2020
Chromosomal translocations involving the KMT2A gene are among the most common genetic alterations found in pediatric acute myeloid leukemias although the molecular mechanisms that initiate the disease remain incompletely defined.
Thomas Milan   +11 more
doaj   +1 more source

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